Bradykinin (1-3) (CAS 23815-91-0)

Bradykinin (1-3) is a truncated form of bradykinin, a vasoactive peptide involved in various physiological processes, including inflammation, pain sensation, and vascular permeability regulation. Research on Bradykinin (1-3) has predominantly focused on its molecular mechanisms of action and its implications in physiological and pathological conditions. This truncated peptide is known to exert its effects primarily through activation of bradykinin receptors, particularly the B2 receptor subtype. Mechanistically, Bradykinin (1-3) binds to B2 receptors, leading to intracellular signaling events such as activation of phospholipase C, release of intracellular calcium ions, and stimulation of nitric oxide and prostaglandin synthesis. These signaling cascades mediate the biological actions of Bradykinin (1-3), including vasodilation, smooth muscle contraction, and modulation of inflammatory responses. In research settings, Bradykinin (1-3) has been utilized as a tool to explain the physiological roles of bradykinin receptors and their downstream signaling pathways. Additionally, this truncated peptide has been employed in experimental models to investigate the pathophysiology of conditions associated with bradykinin dysregulation, such as hypertension, pain disorders, and inflammatory diseases. Furthermore, Bradykinin (1-3) has been instrumental in studying the structure-activity relationships of bradykinin analogs and in exploring novel strategies for targeting the bradykinin system in various research contexts. Overall, Bradykinin (1-3) serves as a valuable tool in biochemical and pharmacological research, offering insights into the complex mechanisms underlying bradykinin signaling and its physiological significance.