Molecular structure of BQ 788 sodium salt, CAS Number: 156161-89-6
BQ 788 sodium salt (CAS 156161-89-6)
See product citations (2)
Alternate Names:
N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D- norleucine sodium salt
Application:
BQ 788 sodium salt is a selective Endothelin receptor B (ETBR) antagonist
CAS Number:
156161-89-6
Purity:
≥95%
Molecular Weight:
663.79
Molecular Formula:
C34H50N5O7•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BQ 788 sodium salt is a selective ETBR (Endothelin receptor B) antagonist. It is also an inhibitor of JAK3, Janus kinase 3. Its application in various research studies has provided valuable insights into the consequences of JAK3 inhibition. In vitro investigations using BQ-788 have showed its impact on biological processes, including inflammation, immune responses, and cancer. A notable study harnessed BQ-788 to examine how JAK3 inhibition influences the production of inflammatory cytokines in human monocytes.
BQ 788 sodium salt (CAS 156161-89-6) References
- Hypotensive effect of endothelin-1 in nitric oxide-deprived, hypertensive pregnant rats. | Matz, RL., et al. 2001. Am J Hypertens. 14: 585-91. PMID: 11411740
- International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature. | Davenport, AP. 2002. Pharmacol Rev. 54: 219-26. PMID: 12037137
- BQ-788, a selective endothelin ET(B) receptor antagonist. | Okada, M. and Nishikibe, M. 2002. Cardiovasc Drug Rev. 20: 53-66. PMID: 12070534
- Catestatin (chromogranin A344-364) is a novel cardiosuppressive agent: inhibition of isoproterenol and endothelin signaling in the frog heart. | Mazza, R., et al. 2008. Am J Physiol Heart Circ Physiol. 295: H113-22. PMID: 18469147
- Age-associated alterations in retinal arteriole reactivity to endothelin-1 differ between the sexes. | MacIntyre, JN., et al. 2012. Mech Ageing Dev. 133: 611-9. PMID: 22906761
- Intracellular endothelin type B receptor-driven Ca2+ signal elicits nitric oxide production in endothelial cells. | Deliu, E., et al. 2012. J Biol Chem. 287: 41023-31. PMID: 23086942
- Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. | Chen, Y., et al. 2016. Sci Signal. 9: ra74. PMID: 27460988
- Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay. | Qu, L., et al. 2020. Naunyn Schmiedebergs Arch Pharmacol. 393: 937-950. PMID: 31781785
- Endothelin-1 drives invadopodia and interaction with mesothelial cells through ILK. | Masi, I., et al. 2021. Cell Rep. 34: 108800. PMID: 33657382
- Inhibition of endothelin A receptor by a novel, selective receptor antagonist enhances morphine-induced analgesia: Possible functional interaction of dimerized endothelin A and μ-opioid receptors. | Kuroda, Y., et al. 2021. Biomed Pharmacother. 141: 111800. PMID: 34175819
- Quantitative real-time measurement of endothelin-1-induced contraction in single non-activated hepatic stellate cells. | Dohi, N., et al. 2021. PLoS One. 16: e0255656. PMID: 34343209
- Upregulation of AQP4 Improves Blood-Brain Barrier Integrity and Perihematomal Edema Following Intracerebral Hemorrhage. | Jeon, H., et al. 2021. Neurotherapeutics. 18: 2692-2706. PMID: 34545550
- Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788. | Ishikawa, K., et al. 1994. Proc Natl Acad Sci U S A. 91: 4892-6. PMID: 8197152
Inhibitor of:
ETBR, GPR171, and NMDAε4.Activator of:
SNRPC.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BQ 788 sodium salt, 1 mg | sc-203534 | 1 mg | $312.00 | |||
BQ 788 sodium salt, 5 mg | sc-203534A | 5 mg | $1272.00 | |||
BQ 788 sodium salt, 25 mg | sc-203534B | 25 mg | $4902.00 |