Molecular structure of BQ-610, CAS Number: 141595-53-1
BQ-610 (CAS 141595-53-1)
Alternate Names:
Hexahydroazepinocarbonyl-leucyl-tryptophyl(cho)-tryptophan
Application:
BQ-610 is a highly selective ETA receptor antagonist
CAS Number:
141595-53-1
Purity:
≥90%
Molecular Weight:
656.7
Molecular Formula:
C36H44N6O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A highly selective ETA receptor antagonist (IC50= 20 nM) which attenuates ET-induced reduction in cardiac output. It also inhibits ET-1- and ET-3-induced activation of adenylate cyclase (IC50= 28.2 nM). BQ-610 is 30-fold more potent than BQ-123, in porcine aortic smooth muscle membrane assay.
BQ-610 (CAS 141595-53-1) References
- Impact of the endothelin-A receptor antagonist BQ 610 on microcirculation in global cerebral ischemia and reperfusion. | Lehmberg, J., et al. 2003. Brain Res. 961: 277-86. PMID: 12531495
- The effects of endothelin antagonist BQ-610 on cerebral vascular wall following experimental subarachnoid hemorrhage and cerebral vasospasm. | Cirak, B., et al. 2004. Clin Auton Res. 14: 197-201. PMID: 15241650
- Endothelin-1 induces lipolysis in 3T3-L1 adipocytes. | Juan, CC., et al. 2005. Am J Physiol Endocrinol Metab. 288: E1146-52. PMID: 15671081
- Intrauterine infusion of BQ-610, an endothelin type A receptor antagonist, delays luteolysis in dairy heifers. | Keator, CS., et al. 2008. Domest Anim Endocrinol. 34: 411-8. PMID: 18258406
- Functional characteristics of alpha adrenergic and endothelinergic receptors in pressurized rat mesenteric veins. | Enouri, S., et al. 2013. Can J Physiol Pharmacol. 91: 538-46. PMID: 23826642
- Endothelin-1 contributes to ischemia/reperfusion injury in isolated rat heart-attenuation of ischemic injury by the endothelin-1 antagonists BQ123 and BQ610. | Han, H., et al. 1995. J Mol Cell Cardiol. 27: 761-6. PMID: 7776381
- Protective effect of the specific endothelin-1 antagonist BQ610 on mechanical function and energy metabolism during ischemia/reperfusion injury in isolated perfused rat hearts. | Illing, B., et al. 1996. J Cardiovasc Pharmacol. 27: 487-94. PMID: 8847864
- Endothelin-A receptor antagonist BQ-610 blocks cigarette smoke-induced mitogenesis in rat airways and vessels. | Dadmanesh, F. and Wright, JL. 1997. Am J Physiol. 272: L614-8. PMID: 9142933
- ET-1 induces mitogenesis in ovine airway smooth muscle cells via ETA and ETB receptors. | Carratu, P., et al. 1997. Am J Physiol. 272: L1021-4. PMID: 9176269
- Inotropic effects of endothelin-1: interaction with molsidomine and with BQ 610. | Beyer, ME., et al. 1999. Hypertension. 33: 145-52. PMID: 9931095
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ETAR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BQ-610, 500 µg | sc-221380 | 500 µg | $320.00 |