Date published: 2026-4-12
Visit Santa Cruz Animal Health

1-800-457-3801

SCBT Portrait Logo
Seach Input
Contact Us
Sign In Account
Quick Order
Cart (0)
bpV(pic) (CAS 148556-27-8) - chemical structure image
Molecular structure of bpV(pic), CAS Number: 148556-27-8
bpV(pic) (CAS 148556-27-8) - chemical structure image
Molecular structure of bpV(pic), CAS Number: 148556-27-8
bpV(pic): sc-221379. Immunofluorescence staining of methanol-fixed lambda protein phosphatase (sc-200312A) treated (A,B) a
bpV(pic): sc-221379. Immunofluorescence staining of methanol-fixed lambda protein phosphatase (sc-200312A) treated (A,B) and bpV(pic) treated (B) HeLa cells showing nuclear localization and chemical inactivation of lambda phosphatase. Antibody tested: p-NFκB p50 (A-8): sc-271908.
bpV(pic): sc-221379. Western blot analysis of Cofilin 1 phosphorylation in K-562 (A), lambda phosphatase (sc-200312) treat
bpV(pic): sc-221379. Western blot analysis of Cofilin 1 phosphorylation in K-562 (A), lambda phosphatase (sc-200312) treated K-562 (B), bpV(pic) treated K-562 (C) and bpV(pic) and lambda phosphatase treated K-562 (D). Antibody tested: p-Cofilin 1 (H-2): sc-271923. Note inhibition of lambda phosphatase by bpV(pic) in lane D.
Molecular structure of bpV(pic), CAS Number: 148556-27-8

bpV(pic) (CAS 148556-27-8)

5.0(1)
Write a reviewAsk a question

See product citations (11)

Alternate Names:
Dipotassium bisperoxo (picolinato) oxovanadate (V)
Application:
bpV(pic) is a potent protein PTP inhibitor
CAS Number:
148556-27-8
Purity:
≥90%
Molecular Weight:
367.28
Molecular Formula:
C6H4NO7V•2K[2H2O]
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis

BpV(pic) is composed of a vanadate molecule coordinated to picolinic acid (2-carboxypyridine) and potassium, that is thought to act as an insulin mimetic. This compound may act to activate the insulin receptor kinase (IRK) of cultured hepatoma cells, stimulate lipogenesis in adipocytes, and inhibit the dephosphorylation of autophosphorylated insulin receptors and epidermal growth factor receptors of rat liver endosomes. bpV(pic) is also an inhibitor of G6Pase and PTP, and an activator of insulin R.


bpV(pic) (CAS 148556-27-8) References

  1. Stimulation of the ICAM-1 gene transcription by the peroxovanadium compound [bpV(Pic)] involves STAT-1 but not NF-kappa B activation in 293 cells.  |  Audette, M., et al. 2001. Eur J Biochem. 268: 1828-36. PMID: 11248703
  2. Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis.  |  Sury, MD., et al. 2011. Neurobiol Dis. 41: 201-8. PMID: 20875857
  3. Effects of bpV(pic) and bpV(phen) on H9c2 cardiomyoblasts during both hypoxia/reoxygenation and H2O2-induced injuries.  |  Tian, Y., et al. 2012. Mol Med Rep. 5: 852-8. PMID: 22200881
  4. Preclinical evaluation of dipotassium bisperoxo (picolinato) oxovanadate V for the treatment of pediatric low-grade gliomas.  |  Ajeawung, NF., et al. 2013. Future Oncol. 9: 1215-29. PMID: 23902250
  5. Administration of a PTEN inhibitor BPV(pic) attenuates early brain injury via modulating AMPA receptor subunits after subarachnoid hemorrhage in rats.  |  Chen, Y., et al. 2015. Neurosci Lett. 588: 131-6. PMID: 25575796
  6. Reactivation of the PI3K/Akt Signaling Pathway by the Bisperoxovanadium Compound bpV(pic) Attenuates Photoreceptor Apoptosis in Experimental Retinal Detachment.  |  Mao, D. and Sun, X. 2015. Invest Ophthalmol Vis Sci. 56: 5519-32. PMID: 26284558
  7. The PTEN inhibitor bpV(pic) promotes neuroprotection against amyloid β-peptide (25-35)-induced oxidative stress and neurotoxicity.  |  Liu, XY., et al. 2017. Neurol Res. 39: 758-765. PMID: 28436304
  8. ERK 1/2 Activation Mediates the Neuroprotective Effect of BpV(pic) in Focal Cerebral Ischemia-Reperfusion Injury.  |  Liu, R., et al. 2018. Neurochem Res. 43: 1424-1438. PMID: 29882124
  9. Bisperoxovanadium protects against spinal cord injury by regulating autophagy via activation of ERK1/2 signaling.  |  Tang, YJ., et al. 2019. Drug Des Devel Ther. 13: 513-521. PMID: 30774313
  10. BpV(pic) confers neuroprotection by inhibiting M1 microglial polarization and MCP-1 expression in rat traumatic brain injury.  |  Liu, R., et al. 2019. Mol Immunol. 112: 30-39. PMID: 31075560
  11. PTEN Inhibition Protects Against Experimental Intracerebral Hemorrhage-Induced Brain Injury Through PTEN/E2F1/β-Catenin Pathway.  |  Zhao, D., et al. 2019. Front Mol Neurosci. 12: 281. PMID: 31866820
  12. Bisperoxovanadium promotes motor neuron survival and neuromuscular innervation in amyotrophic lateral sclerosis.  |  Wang, J., et al. 2021. Mol Brain. 14: 155. PMID: 34635126
  13. Cryogenic 3D Printing of ß-TCP/PLGA Composite Scaffolds Incorporated With BpV (Pic) for Treating Early Avascular Necrosis of Femoral Head.  |  Li, F., et al. 2021. Front Bioeng Biotechnol. 9: 748151. PMID: 35118053
  14. Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.  |  Posner, BI., et al. 1994. J Biol Chem. 269: 4596-604. PMID: 8308031
  15. A stable peroxovanadium compound with insulin-like action in human fat cells.  |  Eriksson, JW., et al. 1996. Diabetologia. 39: 235-42. PMID: 8635677

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

bpV(pic), 5 mg

sc-221379
5 mg
$88.00

bpV(pic), 25 mg

sc-221379A
25 mg
$334.00
1-800-457-3801
Visit Santa Cruz Animal Health|Visit San Juan Ranch
Santa Cruz Animal Health is a leading provider of animal health care products. ©2026 Santa Cruz Biotechnology Inc. All Rights Reserved.
Toll-Free: 1-800-457-3801 - Terms & Conditions | Privacy Policy | Legal
“Santa Cruz Animal Health”, “San Juan Ranch”, the San Juan Ranch logo, “UltraCruz”, “Supplement of Champions”, are registered trademarks of Santa Cruz Biotechnology, Inc. All other trademarks are the property of their respective owners.