bpV(HOpic): sc-221377. Immunofluorescence staining of methanol-fixed lambda protein phosphatase (sc-200312A) treated (A,B) and bpV(HOpic) treated (B) HeLa cells showing nuclear localization and chemical inactivation of lambda phosphatase. Antibody tested: p-NFκB p50 (Ser 337): sc-33022.
bpV(HOpic) (CAS 722494-26-0)
See product citations (19)
Alternate Names:
Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V); Bisperoxovanadium(HOpic)
Application:
bpV(HOpic) is a protein PTP inhibitor
CAS Number:
722494-26-0
Purity:
≥95%
Molecular Weight:
347.24
Molecular Formula:
VO8C6H4N•2K
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
bpV(HOpic) is a bisperoxo oxovanadate dipotassium salt coordinated to 5-hydroxypyridine-2-carboxylate. This vanadium compound may act to be a potent inhibitor of protein phosphotyrosine phosphatase (PTP) and PTEN, and has been described to act as an insulin mimetic. This compound may act to activate the insulin receptor kinase of hepatoma cells, stimulate lipogenesis in adipocytes, and to enhance PI3K/Akt signaling that could prevent ischemia-reperfusion (I/R) injury to the myocardium.
bpV(HOpic) (CAS 722494-26-0) References
- Bisperoxovanadium compounds are potent PTEN inhibitors. | Schmid, AC., et al. 2004. FEBS Lett. 566: 35-8. PMID: 15147864
- Ischemic preconditioning-induced cardioprotection is lost in mice with immunoproteasome subunit low molecular mass polypeptide-2 deficiency. | Cai, ZP., et al. 2008. FASEB J. 22: 4248-57. PMID: 18728217
- Pharmacological inhibition of PTEN limits myocardial infarct size and improves left ventricular function postinfarction. | Keyes, KT., et al. 2010. Am J Physiol Heart Circ Physiol. 298: H1198-208. PMID: 20097771
- Pharmacological postconditioning protects against hepatic ischemia/reperfusion injury. | Dal Ponte, C., et al. 2011. Liver Transpl. 17: 474-82. PMID: 21445931
- Phospho-tyrosine phosphatase inhibitor Bpv(Hopic) enhances C2C12 myoblast migration in vitro. Requirement of PI3K/AKT and MAPK/ERK pathways. | Dimchev, GA., et al. 2013. J Muscle Res Cell Motil. 34: 125-36. PMID: 23553034
- Inhibition of phosphatase and tensin homologue (PTEN) in human ovary in vitro results in increased activation of primordial follicles but compromises development of growing follicles. | McLaughlin, M., et al. 2014. Mol Hum Reprod. 20: 736-44. PMID: 24830779
- Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response. | Maidarti, M., et al. 2019. Hum Reprod. 34: 297-307. PMID: 30521029
- The effect of bpV(HOpic) on in vitro activation of primordial follicles in cultured swine ovarian cortical strips. | Raffel, N., et al. 2019. Reprod Domest Anim. 54: 1057-1063. PMID: 31087697
- Human Follicle in vitro Culture Including Activation, Growth, and Maturation: A Review of Research Progress. | Yang, Q., et al. 2020. Front Endocrinol (Lausanne). 11: 548. PMID: 32849312
- Porous Silicon Nanoparticles Embedded in Poly(lactic-co-glycolic acid) Nanofiber Scaffolds Deliver Neurotrophic Payloads to Enhance Neuronal Growth. | Zuidema, JM., et al. 2020. Adv Funct Mater. 30: PMID: 32982626
- PTEN inhibitor bpV(HOpic) confers protection against ionizing radiation. | Chauhan, A., et al. 2021. Sci Rep. 11: 1720. PMID: 33462262
- The effect of mTOR activation and PTEN inhibition on human primordial follicle activation in ovarian tissue culture. | Ghezelayagh, Z., et al. 2022. J Assist Reprod Genet. 39: 1739-1747. PMID: 35819576
- Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. | Posner, BI., et al. 1994. J Biol Chem. 269: 4596-604. PMID: 8308031
Inhibitor of:
PTEN, and PTP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
bpV(HOpic), 5 mg | sc-221377 | 5 mg | $95.00 | |||
bpV(HOpic), 25 mg | sc-221377A | 25 mg | $331.00 |