Date published: 2025-12-2

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Boromycin (CAS 34524-20-4)

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Alternate Names:
Antibiotic A 28829; Ivomycin; NSC216128
Application:
Boromycin is a Boron-containg macrolide antibiotic
CAS Number:
34524-20-4
Molecular Weight:
879.87
Molecular Formula:
C45H74BNO15
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Boromycin is a Boron-containing macrolide antibiotic with many functions that includes antibacterial, antiprotozoal (Plasmodium, Babesia), anti-HIV compound, Ca2+ homeostasis modulator, potentiator of bleomycin-induced anti-tumor activity and is used as a chiral selector in capillary electrophoresis. The incorporation of boron into its molecular structure gives boromycin distinctive chemical and biological properties. The presence of boron is for its biological activity, as it forms a complex with cell membrane components, disrupting cellular processes. Boromycin′s mechanism of action is primarily targeting the cell membrane′s ion transport processes. It has a high affinity for potassium ions, interfering with the ion gradients essential for cellular homeostasis.


Boromycin (CAS 34524-20-4) References

  1. Boromycin abrogates bleomycin-induced G2 checkpoint.  |  Arai, M., et al. 2004. J Antibiot (Tokyo). 57: 662-8. PMID: 15638327
  2. Empirical observations and mechanistic insights on the first boron-containing chiral selector for LC and supercritical fluid chromatography.  |  Wang, C., et al. 2007. Anal Chem. 79: 8125-35. PMID: 17892273
  3. Biologically active compounds of semi-metals.  |  Rezanka, T. and Sigler, K. 2008. Phytochemistry. 69: 585-606. PMID: 17991498
  4. Study on the use of boromycin as a chiral selector in capillary electrophoresis.  |  Maier, V., et al. 2012. J Chromatogr A. 1237: 128-32. PMID: 22475183
  5. Total synthesis of macrodiolide ionophores aplasmomycin A and boromycin via double ring contraction.  |  Avery, MA., et al. 2014. Org Biomol Chem. 12: 9116-32. PMID: 25096282
  6. Boromycin Kills Mycobacterial Persisters without Detectable Resistance.  |  Moreira, W., et al. 2016. Front Microbiol. 7: 199. PMID: 26941723
  7. Aplasmomycin and boromycin are specific inhibitors of the futalosine pathway.  |  Shimizu, Y., et al. 2018. J Antibiot (Tokyo). 71: 968-970. PMID: 30089869
  8. Boromycin Has Potent Anti-Toxoplasma and Anti-Cryptosporidium Activity.  |  Abenoja, J., et al. 2021. Antimicrob Agents Chemother. 65: PMID: 33468470
  9. Role and Mechanism of Keap1/Nrf2 Signaling Pathway in the Regulation of Autophagy in Alleviating Pulmonary Fibrosis.  |  Dong, Z., et al. 2022. Comput Intell Neurosci. 2022: 3564871. PMID: 35898772
  10. Effect of a rat uterine fluid endopeptidase on lysis of the zona pellucida.  |  Rosenfeld, MG. and Joshi, MS. 1981. J Reprod Fertil. 62: 199-203. PMID: 7014858
  11. The tartrolons, new boron-containing antibiotics from a myxobacterium, Sorangium cellulosum.  |  Irschik, H., et al. 1995. J Antibiot (Tokyo). 48: 26-30. PMID: 7532644
  12. Induction of the cortical reaction in hamster eggs by membrane-active agents.  |  Gwatkin, RB., et al. 1976. J Reprod Fertil. 47: 299-303. PMID: 986469
  13. Antibiotic-induced changes of mycelial growth of Botrytis cinerea.  |  Baráthová, H. and Betina, V. 1976. Folia Microbiol (Praha). 21: 355-61. PMID: 987979

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Boromycin, 250 µg

sc-396247
250 µg
$138.00

Boromycin, 1 mg

sc-396247A
1 mg
$367.00