Date published: 2026-4-5

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Boc-Pro-OH (CAS 15761-39-4)

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Alternate Names:
Boc-L-proline; N-(tert-Butoxycarbonyl)-L-proline
Application:
Boc-Pro-OH is a useful synthetic intermediate
CAS Number:
15761-39-4
Molecular Weight:
215.25
Molecular Formula:
C10H17NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Boc-Pro-OH, a white crystalline powder soluble in ethanol and water, is a derivative of proline, a non-essential amino acid vital for protein biosynthesis. It is extensively applied in a variety of scientific research, especially in the synthesis of peptides, serving as a common protecting group for the amine groups of amino acids during such synthesis. Additionally, Boc-Pro-OH is used as a chiral auxiliary in asymmetric synthesis, underlining its multifaceted applications in scientific experiments. Boc-Pro-OH is a useful synthetic intermediate. It is used to synthesize Daclatasvir which inhibits the HCV protein NS5A.


Boc-Pro-OH (CAS 15761-39-4) References

  1. Visible-Light-Mediated Decarboxylative Radical Additions to Vinyl Boronic Esters: Rapid Access to γ-Amino Boronic Esters.  |  Noble, A., et al. 2018. Angew Chem Int Ed Engl. 57: 2155-2159. PMID: 29316095
  2. Thiocarbonyl-enabled ferrocene C-H nitrogenation by cobalt(III) catalysis: thermal and mechanochemical.  |  Yetra, SR., et al. 2018. Beilstein J Org Chem. 14: 1546-1553. PMID: 30013681
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  4. Discovery of Kynurenines Containing Oligopeptides as Potent Opioid Receptor Agonists.  |  Szűcs, E., et al. 2020. Biomolecules. 10: PMID: 32059524
  5. Imidazopyridine-fused [1,3]diazepinones: modulations of positions 2 to 4 and their impacts on the anti-melanoma activity.  |  Baccon-Sollier, PL., et al. 2020. J Enzyme Inhib Med Chem. 35: 935-949. PMID: 32249633
  6. Altering the Sex Pheromone Cyclo(l-Pro-l-Pro) of the Diatom Seminavis robusta towards a Chemical Probe.  |  Bonneure, E., et al. 2021. Int J Mol Sci. 22: PMID: 33494376
  7. Rapid Optimization of Photoredox Reactions for Continuous-Flow Systems Using Microscale Batch Technology.  |  González-Esguevillas, M., et al. 2021. ACS Cent Sci. 7: 1126-1134. PMID: 34345665
  8. An efficient one-pot conversion of carboxylic acids into benzimidazoles via an HBTU-promoted methodology.  |  Barasa, L. and Yoganathan, S. 2018. RSC Adv. 8: 35824-35830. PMID: 35547918
  9. The Anti-Tubercular Aminolipopeptide Trichoderin A Displays Selective Toxicity against Human Pancreatic Ductal Adenocarcinoma Cells Cultured under Glucose Starvation.  |  Kasim, JK., et al. 2023. Pharmaceutics. 15: PMID: 36678914
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  11. Organocatalysis with carbon nitrides.  |  Ruban, SM., et al. 2023. Sci Technol Adv Mater. 24: 2188879. PMID: 37007670
  12. Regioselective Cyclic Iminium Formation of Ugi Advanced Intermediates: Rapid Access to 3,4-Dihydropyrazin-2(1H)-ones and Other Diverse Nitrogen-Containing Heterocycles.  |  Cankařová, N. and Krchňák, V. 2023. Molecules. 28: PMID: 37049824
  13. The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands.  |  Ericson, MD., et al. 2023. Int J Mol Sci. 24: PMID: 37373293

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Boc-Pro-OH, 5 g

sc-300292
5 g
$31.00

Boc-Pro-OH, 25 g

sc-300292A
25 g
$84.00