Molecular structure of Boc-Lys(Tfa)-AMC, CAS Number: 97885-44-4
Boc-Lys(Tfa)-AMC (CAS 97885-44-4)
Application:
Boc-Lys(Tfa)-AMC is a fluorogenic substrate for the assaying of histone deacetylase 4, 5, 7
CAS Number:
97885-44-4
Purity:
≥98%
Molecular Weight:
499.49
Molecular Formula:
C23H28F3N3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Boc-Lys(Tfa)-AMC is a derivative of the amino acid lysine, which has been modified to contain a tert-butyloxycarbonyl (Boc) group and a trifluoroacetic acid (Tfa) group. The Tfa group acts as an acid catalyst. Boc-Lys(Tfa)-AMC is a fluorogenic substrate for the assaying of histone deacetylase (HDAC) 4, 5 and 7 activity in a protease-coupled assay. It is also a suitable substrate for HDAC 8. The deacylated product Boc-Lys-AMC corresponds to I-1880. Additionally, Boc-Lys(Tfa)-AMC is an important reagent in the synthesis of peptides, proteins, and other peptidomimetics. Furthermore, it is employed in the study of enzyme inhibition, as it may act to be a potent inhibitor of serine proteases.
Boc-Lys(Tfa)-AMC (CAS 97885-44-4) References
- Members of the histone deacetylase superfamily differ in substrate specificity towards small synthetic substrates. | Riester, D., et al. 2004. Biochem Biophys Res Commun. 324: 1116-23. PMID: 15485670
- Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. | Lahm, A., et al. 2007. Proc Natl Acad Sci U S A. 104: 17335-40. PMID: 17956988
- Isomer-specific biodegradation of nonylphenol in river sediments and structure-biodegradability relationship. | Lu, Z. and Gan, J. 2014. Environ Sci Technol. 48: 1008-14. PMID: 24345275
Substrate of:
Fluorogenic.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Boc-Lys(Tfa)-AMC, 50 mg | sc-300290 | 50 mg | $214.00 | |||
Boc-Lys(Tfa)-AMC, 250 mg | sc-300290A | 250 mg | $857.00 |