Molecular structure of Boc-L-aspartic acid beta-benzyl ester chloromethylketone, CAS Number: 172702-58-8
Boc-L-aspartic acid beta-benzyl ester chloromethylketone (CAS 172702-58-8)
Alternate Names:
Boc-Asp(OBzl)-CMK
Application:
Boc-L-aspartic acid beta-benzyl ester chloromethylketone is an Apoptosis inhibitor
CAS Number:
172702-58-8
Purity:
≥95%
Molecular Weight:
355.81
Molecular Formula:
C17H22NO5Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Boc-L-aspartic acid beta-benzyl ester chloromethylketone is cell penetrable. This inhibitor has been shown to bind covalently to the active site of ICE, reducing ICE-mediated processing of mature interleukin-1β in a monocytic cell line without affecting tumor necrosis factor processing.
Boc-L-aspartic acid beta-benzyl ester chloromethylketone (CAS 172702-58-8) References
- HIV-1 coat protein gp120 stimulates interleukin-1beta secretion from human neuroblastoma cells: evidence for a role in the mechanism of cell death. | Corasaniti, MT., et al. 2001. Br J Pharmacol. 134: 1344-50. PMID: 11704656
- Ionic mechanism of ouabain-induced concurrent apoptosis and necrosis in individual cultured cortical neurons. | Xiao, AY., et al. 2002. J Neurosci. 22: 1350-62. PMID: 11850462
- Fusarenon-X induced apoptosis in HL-60 cells depends on caspase activation and cytochrome c release. | Miura, K., et al. 2002. Toxicology. 172: 103-12. PMID: 11882350
- Neurobiological mediators of neuronal apoptosis in experimental neuroAIDS. | Corasaniti, MT., et al. 2003. Toxicol Lett. 139: 199-206. PMID: 12628755
- Caspase-1 inhibitors abolish deleterious enhancement of COX-2 expression induced by HIV-1 gp120 in human neuroblastoma cells. | Corasaniti, MT., et al. 2003. Toxicol Lett. 139: 213-9. PMID: 12628757
- HIV neurotoxicity: potential therapeutic interventions. | Wallace, DR. 2006. J Biomed Biotechnol. 2006: 65741. PMID: 17047310
- The broad-spectrum caspase inhibitor Boc-Asp-CMK induces cell death in human leukaemia cells. | Frydrych, I., et al. 2008. Toxicol In Vitro. 22: 1356-60. PMID: 18434077
- Possible involvement of caspase-7 in cell cycle progression at mitosis. | Hashimoto, T., et al. 2008. Genes Cells. 13: 609-21. PMID: 18459962
- Contribution of caspase(s) to the cell cycle regulation at mitotic phase. | Hashimoto, T., et al. 2011. PLoS One. 6: e18449. PMID: 21479177
- Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. | Boudreau, N., et al. 1995. Science. 267: 891-3. PMID: 7531366
Inhibitor of:
Apoptosis.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Boc-L-aspartic acid beta-benzyl ester chloromethylketone, 100 mg | sc-285170 | 100 mg | $1400.00 | |||
Boc-L-aspartic acid beta-benzyl ester chloromethylketone, 250 mg | sc-285170A | 250 mg | $1076.00 |