Molecular structure of Boc-Ile-OSu, CAS Number: 3392-08-3
Boc-Ile-OSu (CAS 3392-08-3)
CAS Number:
3392-08-3
Molecular Weight:
328.36
Molecular Formula:
C15H24N2O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Boc-Ile-OSu is a potent inhibitor of the bacterial biosynthetic pathway.It blocks the synthesis of the amino acid L-isoleucine by binding to the enzyme IleS synthetase, which is responsible for the conversion of L-threonine to L-isoleucine in bacteria. Through its benzodiazepine receptor ligand properties, Boc-Ile-OSu has shown to have inhibitory effects on bacterial growth in vitro. By binding to the outer membrane of Gram-negative bacteria, it causes leakeage of the cytoplasmic membrane, resulting in cell death. Furthermore, this compound also inhibits the binding of methicillin-resistant Staphylococcus aureus (MRSA) to human cells.
Boc-Ile-OSu (CAS 3392-08-3) References
- Synthesis of a new biological response modifier thyrnosin beta(4) analogue and its restorative effect on depressed. | Abiko, T. and Sekino, H. 1992. Mediators Inflamm. 1: 113-9. PMID: 18475450
- Synthesis and Biological Evaluation of Lipophilic Nucleoside Analogues as Inhibitors of Aminoacyl-tRNA Synthetases. | Nautiyal, M., et al. 2019. Antibiotics (Basel). 8: PMID: 31600972
- Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors. | Zhang, B., et al. 2020. Molecules. 25: PMID: 33081246
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Boc-Ile-OSu, 5 g | sc-227479 | 5 g | $71.00 |