Date published: 2025-12-8

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Boc-Cys(Trt)-OH (CAS 21947-98-8)

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CAS Number:
21947-98-8
Purity:
≥98%
Molecular Weight:
463.59
Molecular Formula:
C27H29NO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Boc-Cys(Trt)-OH is a derivative of cysteine, an amino acid that plays a role in the formation of proteins. Boc-Cys(Trt)-OH is a building block for the synthesis of peptides and proteins. Boc-Cys(Trt)-OH is for its ability to protect the thiol group of cysteine in peptide synthesis. Boc-Cys(Trt)-OH is utilized in the solid-phase peptide synthesis due to its stability and compatibility with a wide range of chemical reactions. Boc-Cys(Trt)-OH is an effective reagent for the selective modification of cysteine residues in proteins, allowing for the study of their structure and function. In biochemistry, Boc-Cys(Trt)-OH is investigating the role of cysteine residues in protein-protein interactions.


Boc-Cys(Trt)-OH (CAS 21947-98-8) References

  1. Early-Stage Incorporation Strategy for Regioselective Labeling of Peptides using the 2-Cyanobenzothiazole/1,2-Aminothiol Bioorthogonal Click Reaction.  |  Chen, KT., et al. 2018. ChemistryOpen. 7: 256-261. PMID: 29531889
  2. Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates.  |  Aguiar, L., et al. 2019. Molecules. 24: PMID: 31842498
  3. Redox-Responsive Dipeptide Nanostructures toward Targeted Cancer Therapy.  |  Chibh, S., et al. 2020. ACS Omega. 5: 3365-3375. PMID: 32118151
  4. Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation.  |  Jin, S., et al. 2020. Nat Commun. 11: 2793. PMID: 32493905
  5. Insights into the Membranolytic Activity of Antimalarial Drug-Cell Penetrating Peptide Conjugates.  |  Aguiar, L., et al. 2020. Membranes (Basel). 11: PMID: 33375073
  6. 2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease.  |  Patil, NA., et al. 2021. ACS Med Chem Lett. 12: 732-737. PMID: 34055219
  7. A biocompatible stapling reaction for in situ generation of constrained peptides.  |  Morewood, R. and Nitsche, C. 2020. Chem Sci. 12: 669-674. PMID: 34163798
  8. Chemical Synthesis of a Potent Antimicrobial Peptide Murepavadin Using a Tandem Native Chemical Ligation/Desulfurization Reaction.  |  Chaudhuri, D., et al. 2021. J Org Chem. 86: 15242-15246. PMID: 34641669
  9. In Silico Screening of a Bile Acid Micelle Disruption Peptide for Oral Consumptions from Edible Peptide Database.  |  Imai, K., et al. 2021. Foods. 10: PMID: 34681544
  10. Development of Novel 191Pt-Labeled Hoechst33258: 191Pt Is More Suitable than 111In for Targeting DNA.  |  Obata, H., et al. 2022. J Med Chem. 65: 5690-5700. PMID: 35358392
  11. Hydrophobicity is a key determinant in the activity of arginine-rich cell penetrating peptides.  |  Allen, J. and Pellois, JP. 2022. Sci Rep. 12: 15981. PMID: 36156072
  12. Functionalized Ultrasmall Iron Oxide Nanoparticles for T1-Weighted Magnetic Resonance Imaging of Tumor Hypoxia.  |  Yang, L., et al. 2022. Molecules. 27: PMID: 36296522
  13. Straightforward Creation of Possibly Prebiotic Complex Mixtures of Thiol-Rich Peptides.  |  Shalayel, I., et al. 2023. Life (Basel). 13: PMID: 37109512

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Boc-Cys(Trt)-OH, 5 g

sc-254991
5 g
$99.00