Molecular structure of BMY 7378 dihydrochloride, CAS Number: 21102-95-4
BMY 7378 dihydrochloride (CAS 21102-95-4)
Alternate Names:
N-(2-(4-(o-Methoxyphenyl)-1-piperazinyl)ethyl)-1,1-cyclopentanediacetimide dihydrochloride
Application:
BMY 7378 dihydrochloride is a SR-1A agonist and a selective α1D-AR antagonist
CAS Number:
21102-95-4
Molecular Weight:
458.42
Molecular Formula:
C22H31N3O3•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BMY 7378 dihydrochloride is a compound that functions as a selective antagonist of the α1A-adrenergic receptor. It acts by binding to and blocking the activity of the α1A-adrenergic receptor, which is a G protein-coupled receptor located in smooth muscle cells. By inhibiting the α1A-adrenergic receptor, BMY 7378 dihydrochloride interferes with the signaling pathways involved in smooth muscle contraction, ultimately leading to relaxation of the smooth muscle. Bmy 7378 Dihydrochloride′s mechanism of action involves targeting the α1A-adrenergic receptor and preventing its activation by endogenous ligands, thereby modulating cellular responses mediated by this receptor.
BMY 7378 dihydrochloride (CAS 21102-95-4) References
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- The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. | Greuel, JM. and Glaser, T. 1992. Eur J Pharmacol. 211: 211-9. PMID: 1535319
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- Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist, BMY 7378. | Sharp, T., et al. 1990. Eur J Pharmacol. 176: 331-40. PMID: 1970304
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- The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. | Piascik, MT., et al. 1995. J Pharmacol Exp Ther. 275: 1583-9. PMID: 8531132
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Inhibitor of:
α1D-AR, and alpha1D-AR.Activator of:
SR-1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMY 7378 dihydrochloride, 10 mg | sc-203849 | 10 mg | $97.00 | |||
BMY 7378 dihydrochloride, 50 mg | sc-203849A | 50 mg | $302.00 |