Molecular structure of BMS 961, CAS Number: 185629-22-5
BMS 961 (CAS 185629-22-5)
Alternate Names:
3-Fluoro-4-[[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-2-naphthalenyl)acetyl]amino]-benzoic acid
Application:
BMS 961 is a RARγ-selective agonist
CAS Number:
185629-22-5
Molecular Weight:
399.46
Molecular Formula:
C23H26FNO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
BMS 961 is a research chemical that is investigated for its potential as a modulator of cell signaling pathways. It is specifically recognized for its activity in studies related to the function of immune cells. BMS 961 is often used to understand the intricate mechanisms of intracellular signaling and its impact on immune responses. The compound′s effects on the activation, differentiation, and effector functions of various immune cell types are of particular interest. In studies aimed at elucidating the pathways that contribute to immune regulation, BMS 961 serves as a useful tool to dissect the complex network of signals that govern the immune system′s behavior. Additionally, research involving BMS 961 may provide insights into the development of novel strategies for modulating immune functions, which can have broad implications in the field of immunology.
BMS 961 (CAS 185629-22-5) References
- Ligand-dependent activation of transcription in vitro by retinoic acid receptor alpha/retinoid X receptor alpha heterodimers that mimics transactivation by retinoids in vivo. | Dilworth, FJ., et al. 1999. Proc Natl Acad Sci U S A. 96: 1995-2000. PMID: 10051583
- Retinoic acid regulates arterial smooth muscle cell proliferation and phenotypic features in vivo and in vitro through an RARalpha-dependent signaling pathway. | Neuville, P., et al. 1999. Arterioscler Thromb Vasc Biol. 19: 1430-6. PMID: 10364073
- Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. | Géhin, M., et al. 1999. Chem Biol. 6: 519-29. PMID: 10421757
- RAR-independent RXR signaling induces t(15;17) leukemia cell maturation. | Benoit, G., et al. 1999. EMBO J. 18: 7011-8. PMID: 10601023
- Synthetic retinoids: recent developments concerning structure and clinical utility. | Kagechika, H. and Shudo, K. 2005. J Med Chem. 48: 5875-83. PMID: 16161990
- Cyclin H binding to the RARalpha activation function (AF)-2 domain directs phosphorylation of the AF-1 domain by cyclin-dependent kinase 7. | Bour, G., et al. 2005. Proc Natl Acad Sci U S A. 102: 16608-13. PMID: 16275922
- Commitment of mouse embryonic stem cells to the adipocyte lineage requires retinoic acid receptor beta and active GSK3. | Monteiro, MC., et al. 2009. Stem Cells Dev. 18: 457-63. PMID: 18690793
- All-trans retinoic acid suppresses interleukin-6 expression in interleukin-1-stimulated synovial fibroblasts by inhibition of ERK1/2 pathway independently of RAR activation. | Kirchmeyer, M., et al. 2008. Arthritis Res Ther. 10: R141. PMID: 19068145
- A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promoters. | Bruck, N., et al. 2009. EMBO J. 28: 34-47. PMID: 19078967
- Retinoids induce integrin-independent lymphocyte adhesion through RAR-α nuclear receptor activity. | Whelan, JT., et al. 2014. Biochem Biophys Res Commun. 454: 537-42. PMID: 25450689
- Lipid Abundance in Zebrafish Embryos Is Regulated by Complementary Actions of the Endocannabinoid System and Retinoic Acid Pathway. | Fraher, D., et al. 2015. Endocrinology. 156: 3596-609. PMID: 26181105
- ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion. | Chronopoulos, A., et al. 2016. Nat Commun. 7: 12630. PMID: 27600527
- High-throughput assessment of oxidative respiration in fish embryos: Advancing adverse outcome pathways for mitochondrial dysfunction. | Souders, CL., et al. 2018. Aquat Toxicol. 199: 162-173. PMID: 29631217
- RARG variant predictive of doxorubicin-induced cardiotoxicity identifies a cardioprotective therapy. | Magdy, T., et al. 2021. Cell Stem Cell. 28: 2076-2089.e7. PMID: 34525346
Inhibitor of:
Transcription Factor.Activator of:
RAR beta, and RAR gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMS 961, 10 mg | sc-362717 | 10 mg | $306.00 | |||
| US: Only available in the US | ||||||
BMS 961, 50 mg | sc-362717A | 50 mg | $1020.00 | |||
| US: Only available in the US | ||||||