Molecular structure of BMS-790052, CAS Number: 1214735-16-6
BMS-790052 (CAS 1214735-16-6)
Alternate Names:
Daclatasvir
Application:
BMS-790052 is a hepatitis C virus (HCV) NS5A inhibitor
CAS Number:
1214735-16-6
Molecular Weight:
738.88
Molecular Formula:
C40H50N8O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BMS-790052, also known as Daclatasvir, is a compound that has been studied in virology, particularly for its action against the hepatitis C virus (HCV). In biochemistry, BMS-790052 is used to study its inhibitory effects on the NS5A protein, which is for HCV RNA replication. Some are interested in understanding the compound′s mode of binding to the NS5A protein and how this interaction disrupts the viral lifecycle. Studies also focus on the resistance profile of HCV to BMS-790052, exploring the genetic variations that contribute to reduced susceptibility. BMS-790052 serves as a molecular measure in assays designed to screen for potential antiviral compounds with similar mechanisms of action.
BMS-790052 (CAS 1214735-16-6) References
- Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system. | Fridell, RA., et al. 2010. Antimicrob Agents Chemother. 54: 3641-50. PMID: 20585111
- Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-α. | Scheel, TK., et al. 2011. Gastroenterology. 140: 1032-42. PMID: 21111742
- The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein. | Lee, C., et al. 2011. Virology. 414: 10-8. PMID: 21513964
- Discovery of potent hepatitis C virus NS5A inhibitors with dimeric structures. | Lemm, JA., et al. 2011. Antimicrob Agents Chemother. 55: 3795-802. PMID: 21576451
- Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052. | Fridell, RA., et al. 2011. J Virol. 85: 7312-20. PMID: 21593143
- A rugged and accurate liquid chromatography-tandem mass spectrometry method for quantitative determination of BMS-790052 in plasma. | Jiang, H., et al. 2011. J Chromatogr B Analyt Technol Biomed Life Sci. 879: 2064-72. PMID: 21704571
- In vitro activity of BMS-790052 on hepatitis C virus genotype 4 NS5A. | Wang, C., et al. 2012. Antimicrob Agents Chemother. 56: 1588-90. PMID: 22203595
- Hepatitis C virus RNA elimination and development of resistance in replicon cells treated with BMS-790052. | Wang, C., et al. 2012. Antimicrob Agents Chemother. 56: 1350-8. PMID: 22214777
- Impact of a baseline polymorphism on the emergence of resistance to the hepatitis C virus nonstructural protein 5A replication complex inhibitor, BMS-790052. | Sun, JH., et al. 2012. Hepatology. 55: 1692-9. PMID: 22234905
- A sensitive and accurate liquid chromatography-tandem mass spectrometry method for quantitative determination of the novel hepatitis C NS5A inhibitor BMS-790052 (daclastasvir) in human plasma and urine. | Jiang, H., et al. 2012. J Chromatogr A. 1245: 117-21. PMID: 22640838
- Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b. | Suzuki, F., et al. 2012. J Clin Virol. 54: 352-4. PMID: 22658798
- In vitro activity of daclatasvir on hepatitis C virus genotype 3 NS5A. | Wang, C., et al. 2013. Antimicrob Agents Chemother. 57: 611-3. PMID: 23089758
- Synthesis and evaluation of non-dimeric HCV NS5A inhibitors. | Amblard, F., et al. 2013. Bioorg Med Chem Lett. 23: 2031-4. PMID: 23466233
- Asymmetric binding to NS5A by daclatasvir (BMS-790052) and analogs suggests two novel modes of HCV inhibition. | Nettles, JH., et al. 2014. J Med Chem. 57: 10031-43. PMID: 25365735
- Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A. | Sun, JH., et al. 2015. Nature. 527: 245-8. PMID: 26536115
Inhibitor of:
HCV Protease.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMS-790052, 5 mg | sc-364446 | 5 mg | $315.00 | |||
BMS-790052, 50 mg | sc-364446A | 50 mg | $163.00 | |||
BMS-790052, 500 mg | sc-364446B | 500 mg | $388.00 |