BMS-740808 CAS: 280118-23-2
MF: C31H27F3N6O3
MW: 588.58
A highly potent, selective inhibitor of Factor X.

BMS-740808 (CAS 280118-23-2)

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Application: A highly potent, selective inhibitor of Factor X
CAS Number: 280118-23-2
Molecular Weight: 588.58
Molecular Formula: C31H27F3N6O3
* Refer to Certificate of Analysis for lot specific data (including water content).

BMS-740808 is a highly potent, selective inhibitor of Factor X, with Ki of 0.03 nM. BMS-740808 is highly potent with a rapid onset of inhibition (2.7 × 107 M-1 s-1), selective (>1000-fold over other proteases), efficacious in the AVShunt thrombosis model. BMS-740808 is synthesized by modification of employing bicyclic pyrazolo-pyridinone scaffold to Razaxaban, a pyrazole based Factor X inhibitor. Especially for BMS-740808, the introduction of a 3(R)-hydroxyl moiety on the pyrrolidine ring results in a significant enhancement in potency. BMS-740808 also shows the high affinity for thrombin.


References

PMID: 16730984

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6914623
SMILES :
C1CN(C[[email protected]@H]1O)CC2=CC=CC=C2C3=CC=C(C=C3)N4CCC5=C(C4=O)N(N=C5C(F)(F)F)C6=CC7=C(C=C6)ON=C7N

Download SDS (MSDS)

Certificate of Analysis

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