Molecular structure of BMS 299897, CAS Number: 290315-45-6
BMS 299897 (CAS 290315-45-6)
See product citations (1)
Alternate Names:
γ-Secretase Inhibitor XXIV
Application:
BMS 299897 is a potent γ-secretase inhibitor
CAS Number:
290315-45-6
Purity:
≥98%
Molecular Weight:
511.94
Molecular Formula:
C24H21ClF3NO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
BMS 299897 is a potent γ-secretase inhibitor which is noted to inhibit Aβ40 and Aβ42 formation in vitro.
BMS 299897 (CAS 290315-45-6) References
- Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor. | Barten, DM., et al. 2005. J Pharmacol Exp Ther. 312: 635-43. PMID: 15452193
- Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897. | Anderson, JJ., et al. 2005. Biochem Pharmacol. 69: 689-98. PMID: 15670587
- In vitro and in vivo metabolism of a gamma-secretase inhibitor BMS-299897 and generation of active metabolites in milligram quantities with a microbial bioreactor. | Zhang, D., et al. 2006. Curr Drug Metab. 7: 883-96. PMID: 17168689
- Liquid-liquid extraction of strongly protein bound BMS-299897 from human plasma and cerebrospinal fluid, followed by high-performance liquid chromatography/tandem mass spectrometry. | Xue, YJ., et al. 2007. J Pharm Biomed Anal. 43: 1728-36. PMID: 17204392
- Ex vivo occupancy of gamma-secretase inhibitors correlates with brain beta-amyloid peptide reduction in Tg2576 mice. | Goldstein, ME., et al. 2007. J Pharmacol Exp Ther. 323: 102-8. PMID: 17640949
- Qualitative and quantitative characterization of the amyloid beta peptide (Abeta) population in biological matrices using an immunoprecipitation-LC/MS assay. | Ford, MJ., et al. 2008. J Neurosci Methods. 168: 465-74. PMID: 18187205
- The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression. | Burton, CR., et al. 2008. J Biol Chem. 283: 22992-3003. PMID: 18574238
- Studies on the pharmacokinetics and metabolism of a gamma-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction. | Zheng, M., et al. 2009. Xenobiotica. 39: 544-55. PMID: 19480557
- The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer's disease. | Meunier, J., et al. 2013. Eur J Pharmacol. 698: 193-9. PMID: 23123349
- Gamma secretase activity modulates BMP-7-induced dendritic growth in primary rat sympathetic neurons. | Karunungan, K., et al. 2023. Auton Neurosci. 247: 103085. PMID: 37031474
Inhibitor of:
beta-Amyloid, and Gamma-secretase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMS 299897, 25 mg | sc-358829 | 25 mg | $265.00 |