BMS-265246 (CAS 582315-72-8)
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BMS265246 is a potent and selective Cdk1/Cdk2 inhibitor for Cdk1/cyclin-B (IC50 = 6 nM) and Cdk2/cyclin-E (IC50 = 9 nM). BMS265246 inhibits the activity of Cdk4/cycD (IC50 = 0.23 μM) and prevents A2780 Cytox with IC50 of 0.76 μM. BMS265246 when bound to Cdk2, shows the inhibitor resides within the ATP purine binding site and forms important H-bonds with Leu83 on the protein backbone. BMS265246 represents the most potent Cdk/Cdk2 selective analogue from this chemotype. A recent study shows that BMS-265246 inhibits cell proliferation with EC50 ranging from 0.293 μM-0.492 μM in HCT-116 cells. After treatment of BMS-265246, the dominant cell populations are G2-arrested cells having 4N DNA content, large round nuclei, and low DNA intensity.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMS-265246, 5 mg | sc-364440 | 5 mg | $304.00 | |||
BMS-265246, 10 mg | sc-364440A | 10 mg | $555.00 |