Molecular structure of BMS 195614, CAS Number: 253310-42-8
BMS 195614 (CAS 253310-42-8)
Alternate Names:
BMS614
Application:
BMS 195614 is a neutral RARα (retinoic acid receptor α) inhibitor
CAS Number:
253310-42-8
Purity:
≥97%
Molecular Weight:
448.51
Molecular Formula:
C29H24N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BMS 195614 is a selective neutral RARalpha inhibitor and exhibits no significant effect on NCoR binding. The compound potentially decreases agonist-induced coactivator recruitment and SMRT binding to RAR. RARs, or Retinoic Acid Receptors, are nuclear hormone receptors that form heterodimers with RXRs (Retinoid X Receptors).
BMS 195614 (CAS 253310-42-8) References
- Selective retinoids and rexinoids in cancer therapy and chemoprevention. | Zusi, FC., et al. 2002. Drug Discov Today. 7: 1165-74. PMID: 12547017
- Design of selective nuclear receptor modulators: RAR and RXR as a case study. | de Lera, AR., et al. 2007. Nat Rev Drug Discov. 6: 811-20. PMID: 17906643
- Retinoic acid inhibits CD25+ dendritic cell expansion and γδ T-cell activation in experimental autoimmune uveitis. | Liang, D., et al. 2013. Invest Ophthalmol Vis Sci. 54: 3493-503. PMID: 23611991
- Pharmacological activity of retinoic acid receptor alpha-selective antagonists in vitro and in vivo. | Chung, SS., et al. 2013. ACS Med Chem Lett. 4: 446-450. PMID: 24040487
- Male contraception: another Holy Grail. | Murdoch, FE. and Goldberg, E. 2014. Bioorg Med Chem Lett. 24: 419-24. PMID: 24368213
- The combination of vitamins and omega-3 fatty acids has an enhanced anti-inflammatory effect on microglia. | Kurtys, E., et al. 2016. Neurochem Int. 99: 206-214. PMID: 27465516
- Classical dendritic cells mediate fibrosis directly via the retinoic acid pathway in severe eye allergy. | Ahadome, SD., et al. 2016. JCI Insight. 1: PMID: 27595139
- Synthesis of apo-13- and apo-15-lycopenoids, cleavage products of lycopene that are retinoic acid antagonists. | Narayanasamy, S., et al. 2017. J Lipid Res. 58: 1021-1029. PMID: 28250025
- Gut Microbiota Species Can Provoke both Inflammatory and Tolerogenic Immune Responses in Human Dendritic Cells Mediated by Retinoic Acid Receptor Alpha Ligation. | Bene, K., et al. 2017. Front Immunol. 8: 427. PMID: 28458670
- Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist. | Clarke, E., et al. 2018. Bioorg Med Chem. 26: 798-814. PMID: 29288071
- Research update and opportunity of non-hormonal male contraception: Histone demethylase KDM5B-based targeting. | Arifuzzaman, S., et al. 2019. Pharmacol Res. 141: 1-20. PMID: 30550955
- Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation. | Catanese, A., et al. 2019. Autophagy. 15: 1719-1737. PMID: 30939964
- A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV. | Johnson, JS., et al. 2020. Cell Rep. 30: 914-931.e9. PMID: 31968263
- Prediction of Metabolite Concentrations, Rate Constants and Post-Translational Regulation Using Maximum Entropy-Based Simulations with Application to Central Metabolism of Neurospora crassa. | Cannon, WR., et al. 2018. Processes (Basel). 6: PMID: 33824861
- Methods for assessing the interaction of apocarotenoids with vertebrate nuclear receptors. | Harrison, EH. 2022. Methods Enzymol. 674: 391-403. PMID: 36008014
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMS 195614, 10 mg | sc-362715 | 10 mg | $239.00 | |||
BMS 195614, 50 mg | sc-362715A | 50 mg | $999.00 |