Molecular structure of BMS 193885, CAS Number: 186185-03-5
BMS 193885 (CAS 186185-03-5)
Application:
BMS 193885 is a competitive NPY1-R antagonist
CAS Number:
186185-03-5
Purity:
>98%
Molecular Weight:
680.79
Molecular Formula:
C33H42N4O6 C3H6O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Potent, competitive neuropeptide (NPY) Y1 antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. Reduces food intake and body weight via central Y1 inhibition and is brain penetrant.
BMS 193885 (CAS 186185-03-5) References
Poindexter et al (2002) Dihydropyridine neuropeptide Y Y1 receptor antagonists. Bioorg.Med.Chem.Letts. 12 379. Poindexter et al (2004) Dihydropyridine neuropeptide Y Y1 receptor antagonists 2: bioisosteric urea replacements. Bioorg.Med.Chem. 12 507. Antal-Zimanyi et al (2008) Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist. Eur.J.Pharmacol. 590 224.Inhibitor of:
NPY1-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMS 193885, 10 mg | sc-203848 | 10 mg | $235.00 | |||
BMS 193885, 50 mg | sc-203848A | 50 mg | $906.00 |