BMP-6 Antibody (74219.11): sc-57042
- BMP-6 Antibody (74219.11) is a mouse monoclonal IgG2b κ BMP-6 antibody, cited in 4 publications, provided at 50 µg/0.5 ml
- raised against a recombinant protein fragment corresponding to amino acids 296-428 of BMP-6 of human origin
- recommended for detection of BMP-6 of human origin by WB and ELISA; non cross-reactive with recombinant human BMP-2, BMP-4, BMP-5 and BMP-7 under reducing conditions
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for BMP-6 Antibody (74219.11). This work is in progress.
BMP-6 Antibody (74219.11) is a mouse monoclonal IgG2b kappa light chain antibody that detects BMP-6 protein of human origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-BMP-6 antibody (74219.11) is available as a non-conjugated format. Bone morphogenic proteins (BMPs), including BMP-6, are critical members of the transforming growth factor-beta (TGFβ) superfamily, playing essential roles in bone and cartilage development regulation. BMP-6 is particularly important for mesenchymal stem cell differentiation into osteoblasts, which are responsible for bone formation. This process maintains bone density and integrity, and supports fracture healing. BMP-6 interacts with specific receptors, activating intracellular signaling pathways that promote osteogenesis. BMP-6′s bone formation properties make this protein a significant target for bone-related disease research and regenerative medicine. With high sequence homology to other BMPs, BMP-6 is implicated in various developmental processes, highlighting BMP-6′s importance in both embryonic development and adult tissue homeostasis.
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BMP-6 Antibody (74219.11) References:
- Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis. | Ozkaynak, E., et al. 1992. J Biol Chem. 267: 25220-7. PMID: 1460021
- BMP-6 and mesenchymal stem cell differentiation. | Vukicevic, S. and Grgurevic, L. 2009. Cytokine Growth Factor Rev. 20: 441-8. PMID: 19900832
- The transforming growth factor-beta family. | Massagué, J. 1990. Annu Rev Cell Biol. 6: 597-641. PMID: 2177343
- Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. | Celeste, AJ., et al. 1990. Proc Natl Acad Sci U S A. 87: 9843-7. PMID: 2263636
- BMP-6 inhibits the metastasis of MDA-MB-231 breast cancer cells by regulating MMP-1 expression. | Hu, F., et al. 2016. Oncol Rep. 35: 1823-30. PMID: 26751737
- BMP-6 modulates somatostatin effects on luteinizing hormone production by gonadrotrope cells. | Toma, K., et al. 2016. Peptides. 76: 96-101. PMID: 26779985
- Interaction of Melatonin and BMP-6 in Ovarian Steroidogenesis. | Otsuka, F. 2018. Vitam Horm. 107: 137-153. PMID: 29544628
- Novel regulators of bone formation: molecular clones and activities. | Wozney, JM., et al. 1988. Science. 242: 1528-34. PMID: 3201241
- Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo. | Gitelman, SE., et al. 1994. J Cell Biol. 126: 1595-609. PMID: 8089189
- A human Mad protein acting as a BMP-regulated transcriptional activator. | Liu, F., et al. 1996. Nature. 381: 620-3. PMID: 8637600
- Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. | Zhang, Y., et al. 1996. Nature. 383: 168-72. PMID: 8774881
- Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. | McPherron, AC., et al. 1997. Nature. 387: 83-90. PMID: 9139826
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMP-6 Antibody (74219.11) | sc-57042 | 50 µg/0.5 ml | $322.00 |