Molecular structure of BML-286, CAS Number: 294891-81-9
BML-286 (CAS 294891-81-9)
Alternate Names:
2-[[3-[(2-phenylacetyl)amino]benzoyl]amino]benzoic acid
Application:
BML-286 is a Wnt signaling disrupter and cancer cell growth inhibitor
CAS Number:
294891-81-9
Molecular Weight:
374.38
Molecular Formula:
C22H18N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BML-286 is is a derivative of benzoic acid in many different areas, including biochemistry and physiology. It is a cell-permeable compound whose binding of the PDZ domain of dishevelled (Kd = 10.6 muM) disrupts Wnt signaling. Further, BML-286 blocks Wnt3a-induced transcription activity and is able to suppress the Wnt pathway-dependent growth of prostate cancer PC-3 cells in vitro (IC50 = 12.5 muM). BML-286 has an interaction with and can modulate the activity of certain receptors, such as the serotonin and dopamine receptors, as well as certain ion channels, such as the potassium and calcium channels.
BML-286 (CAS 294891-81-9) References
- Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. | Grandy, D., et al. 2009. J Biol Chem. 284: 16256-16263. PMID: 19383605
- Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma. | Ogorodnikov, A., et al. 2018. Nat Commun. 9: 5331. PMID: 30552333
- miR-4757-3p Inhibited the Migration and Invasion of Lung Cancer Cell via Targeting Wnt Signaling Pathway. | Zhao, P., et al. 2023. J Oncol. 2023: 6544042. PMID: 36814555
Inhibitor of:
TCF-4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BML-286, 10 mg | sc-397017 | 10 mg | $210.00 |