Molecular structure of BML-278, CAS Number: 15301-69-6
BML-278 (CAS 15301-69-6)
Alternate Names:
N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine
Application:
BML-278 is a Sirt activator and cell cycle arresting compound
CAS Number:
15301-69-6
Molecular Weight:
391.46
Molecular Formula:
C24H25NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
BML-278 is a selective Sirt1 activator (EC150 = 1μM) structurally based on a dihydropyridine scaffold. It has much weaker effects on Sirt2 and Sirt3. BML-278 is active in whole cells and arrests cell cycle at G1/S phase in U937 cells.
BML-278 (CAS 15301-69-6) References
- High glucose induced alteration of SIRTs in endothelial cells causes rapid aging in a p300 and FOXO regulated pathway. | Mortuza, R., et al. 2013. PLoS One. 8: e54514. PMID: 23342163
- The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers. | Long, J., et al. 2014. J Biol Chem. 289: 35494-502. PMID: 25355313
- Emerging Liver-Kidney Interactions in Nonalcoholic Fatty Liver Disease. | Musso, G., et al. 2015. Trends Mol Med. 21: 645-662. PMID: 26432021
- SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development. | Adamkova, K., et al. 2017. J Anim Sci Biotechnol. 8: 83. PMID: 29118980
- The BET bromodomain inhibitor i-BET151 impairs ovarian cancer metastasis and improves antitumor immunity. | Liu, A., et al. 2018. Cell Tissue Res. 374: 577-585. PMID: 30182276
- Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis progression. | Nevoral, J., et al. 2019. J Anim Sci Biotechnol. 10: 67. PMID: 31413827
- Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau. | Jeong, H., et al. 2019. Int J Mol Sci. 20: PMID: 31480543
- Crosstalk between kidney and liver in non-alcoholic fatty liver disease: mechanisms and therapeutic approaches. | Sharma, N., et al. 2022. Arch Physiol Biochem. 128: 1024-1038. PMID: 32223569
- Sirtuins in female meiosis and in reproductive longevity. | Vazquez, BN., et al. 2020. Mol Reprod Dev. 87: 1175-1187. PMID: 33184962
- Role of NRF2 and Sirtuin activators in COVID-19. | Khan, H., et al. 2021. Clin Immunol. 233: 108879. PMID: 34798239
- RNA sequencing-based screen for reactivation of silenced alleles of autosomal genes. | Gupta, S., et al. 2022. G3 (Bethesda). 12: PMID: 35100361
- Functional Drug Screening of Small Molecule Inhibitors of Epigenetic Modifiers in Refractory AML Patients. | Dennison, JL., et al. 2022. Cancers (Basel). 14: PMID: 36077629
Activator of:
AFF4, and SIRT1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BML-278, 5 mg | sc-396999 | 5 mg | $84.00 | |||
BML-278, 25 mg | sc-396999A | 25 mg | $335.00 |