BML-257 (CAS 32387-96-5)
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BML-257 is an potent inhibitor of AKT1 translocation and has been observed to attenuate cannabinoid agonist-simulated neurosphere proliferation. AKT1 is a gene of the AKT family that encode for serine/threonine kinases. AKT1 is associated with pathways of cellular survival and has been implicated as a factor of various cancers. This product is often utilized in experiments concerning phosphoinostitide-3 kinase signaling and the PI3/AKT pathway. BML-257 also inhibits HCV (hepatitis C virus) NS5B RNA-dependent RNA polymerase (RdRp) with an IC50 value of 79 muM. BML-257 is a compound in the field of chemistry, finding extensive applications in various synthetic processes. It plays a significant role in the synthesis of pharmaceuticals, biochemicals, and industrial chemicals.
BML-257 (CAS 32387-96-5) References
- Identification of Akt pathway inhibitors using redistribution screening on the FLIPR and the IN Cell 3000 analyzer. | Lundholt, BK., et al. 2005. J Biomol Screen. 10: 20-9. PMID: 15695340
- CB2 cannabinoid receptors promote mouse neural stem cell proliferation. | Molina-Holgado, F., et al. 2007. Eur J Neurosci. 25: 629-34. PMID: 17328768
- BML-257, a Small Molecule that Protects against Drug-Induced Liver Injury in Zebrafish. | Jagtap, U., et al. 2022. Chem Res Toxicol. 35: 1393-1399. PMID: 35796757
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BML-257, 10 mg | sc-200666 | 10 mg | $74.00 | |||
BML-257, 50 mg | sc-200666A | 50 mg | $298.00 |