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BML-210 has been shown to inhibit HDAC activity in HeLa nuclear extracts (IC50 = 5-10μM). Furthermore this compound was shown to inhibit growth, stimulate differentiation, and induce apoptosis in several human leukemia cell lines. These effects have been attributed to modulation of histone acetylation levels and subsequent changes in gene expression.
1. Herman, David., et al., 2006. Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nature chemical biology. 2(10): 551-8. PMID: 16921367
2. Savickiene, Jurate., et al., 2006. The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects on the human leukemia cell lines. European journal of pharmacology. 549(1-3): 9-18. PMID: 16978604
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