Molecular structure of BML-190, CAS Number: 2854-32-2
BML-190 (CAS 2854-32-2)
Alternate Names:
IMMA
Application:
BML-190 is a selective and potent ligand for the human cannabinoid CB2 receptor
CAS Number:
2854-32-2
Molecular Weight:
426.89
Molecular Formula:
C23H23ClN2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BML-190 is an indomethacin morpholinylamide which functions as a selective inverse agonist of the human cannabinoid CB2 receptor. It is known that BML-190 binds to both CB1 and CB2 receptors. Studies involving HEK-293 cells indicate that BML-190 increases the accumulation of cAMP, via forskolin-stimulated mechanism. Alternate studies suggest that BML-190 reduces the toxicity of culture supernatants to SH-SY5Y human neutroblastoma cells. Various research suggests that BML-190 is an essential tool in studying the proliferation of neuroblastoma.
BML-190 (CAS 2854-32-2) References
- Bifemelane hydrochloride protects against cytotoxicity of hydrogen peroxide on cultured rat neuroblastoma cell line. | Miyazaki, I., et al. 1999. Neurochem Res. 24: 857-60. PMID: 10403625
- Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids. | Chang, YH., et al. 2001. J Cell Biochem. 81: 715-23. PMID: 11329626
- BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates. | New, DC. and Wong, YH. 2003. FEBS Lett. 536: 157-60. PMID: 12586356
- Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. | Klegeris, A., et al. 2003. Br J Pharmacol. 139: 775-86. PMID: 12813001
- In vitro metabolism of indomethacin morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB(2)) in rat liver microsomes. | Zhang, Q., et al. 2010. Eur J Pharm Sci. 41: 163-72. PMID: 20542112
- Bifemelane hydrochloride reduces plasma beta-endorphin-like immunoreactivity levels in rats. | Mitsuma, T., et al. 1990. Exp Clin Endocrinol. 95: 301-5. PMID: 2245819
- The Aminoalkylindole BML-190 Negatively Regulates Chitosan Synthesis via the Cyclic AMP/Protein Kinase A1 Pathway in Cryptococcus neoformans. | Maybruck, BT., et al. 2019. mBio. 10: PMID: 31848271
- Inhibitory effect of bifemelane on superoxide generation by activated neutrophils measured using a simple chemiluminescence method. | Yoshida, T., et al. 1994. Free Radic Res. 21: 371-6. PMID: 7834051
- Protective effect of bifemelane hydrochloride on ischemic hippocampal CA1 neuronal damage in the gerbil: relation to induction of HSP70. | Liu, XH., et al. 1993. Life Sci. 53: 161-7. PMID: 8515688
- A novel photoaffinity probe for the LTD4 receptor. | Gallant, M., et al. 1998. Bioorg Med Chem. 6: 63-72. PMID: 9502106
Inhibitor of:
CB2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BML-190, 10 mg | sc-203533 | 10 mg | $78.00 | |||
BML-190, 50 mg | sc-203533A | 50 mg | $326.00 |