Blood Group Lewis a/b Antibody (HEA164): sc-73368

Blood Group Lewis a/b Antibody (HEA164) is a mouse monoclonal IgM kappa antibody that detects Blood Group Lewis a/b protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-Blood Group Lewis a/b antibody (HEA164) is available as non-conjugated format. Blood Group Lewis a/b protein plays a crucial role in cell-cell interactions and immune responses, serving as a recognition site for various lectins and pathogens. Blood Group Lewis a/b protein is primarily located on the surface of red blood cells and other tissues, contributing to the formation of specific carbohydrate structures essential for cellular communication and adhesion. These carbohydrate determinants are vital for proper functioning of selectins, which are adhesion molecules facilitating rolling and migration of leukocytes during immune responses. Blood Group Lewis a/b antigens are involved in determining blood group compatibility and can influence susceptibility to certain infections, making Blood Group Lewis a/b significant in both transfusion medicine and immunology.

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Blood Group Lewis a/b Antibody (HEA164) References:

1. Human leukocyte antigen class II genes and Helicobacter pylori infection: does genotype overwhelm environmental exposure?  |  Russo, A., et al. 2003. Nutrition. 19: 708-15. PMID: 12921878
2. Lewis(y) antigen (CD174) and apoptosis in gastric and colorectal carcinomas: correlations with clinical and prognostic parameters.  |  Baldus, SE., et al. 2006. Histol Histopathol. 21: 503-10. PMID: 16493580
3. Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesis.  |  Moehler, TM., et al. 2008. J Cell Physiol. 215: 27-36. PMID: 18205178
4. Co-expression of CD173 (H2) and CD174 (Lewis Y) with CD44 suggests that fucosylated histo-blood group antigens are markers of breast cancer-initiating cells.  |  Lin, WM., et al. 2010. Virchows Arch. 456: 403-9. PMID: 20300773
5. A Furan-Based Lewis-Y-(CD174)-Saccharide Mimetic Inhibits Endothelial Functions and In Vitro Angiogenesis.  |  Sauer, S., et al. 2015. Adv Clin Exp Med. 24: 759-68. PMID: 26768625
6. Role of human milk oligosaccharides in Group B Streptococcus colonisation.  |  Andreas, NJ., et al. 2016. Clin Transl Immunology. 5: e99. PMID: 27588204
7. The Lewis antigen system and its relevance for clinical transplantation.  |  Fischer, E., et al. 1979. Z Immunitatsforsch Immunobiol. 155: 420-3. PMID: 382664
8. [Detection of the Lewis antigen system characteristic of erythrocytes of the secretor group Le(a-b-)].  |  Potapov, MI. 1970. Probl Gematol Pereliv Krovi. 15: 45-9. PMID: 5496725
9. The role of the Lewis antigen system in renal transplantation and allograft rejection.  |  Wick, MR. and Moore, SB. 1984. Mayo Clin Proc. 59: 423-8. PMID: 6374307
10. [The Lewis antigen system as a marker of IHD risk].  |  Zhiburt, BB., et al. 1997. Ter Arkh. 69: 29-31. PMID: 9163045

The preferred Blood Group Lewis b antibody is Blood Group Lewis b Antibody (2-25LE): sc-51513.