Blood Group AB antigen Antibody (Z5H-2/Z2A): sc-52370

Blood Group AB antigen Antibody (Z5H-2/Z2A) is a mouse monoclonal IgM antibody that detects Blood Group AB antigen protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Blood Group AB antigen (Z5H-2/Z2A) antibody is available in both non-conjugated and various conjugated forms, including fluorescein isothiocyanate (FITC), to suit diverse experimental needs. Blood Group AB antigen plays a crucial role in the immune response and is a key determinant in blood transfusion compatibility, making its accurate detection vital in clinical settings. Blood Group AB antigen is primarily located on the surface of erythrocytes and certain epithelial cells, where Blood Group AB antigen contributes to cell-cell recognition and signaling processes. The presence of A and B antigens on red blood cells is determined by specific glycosyltransferases that add sugar moieties to precursor substances, and any alterations in these antigens can lead to serious transfusion reactions or complications in organ transplantation. Blood group antigens undergo changes during malignant transformation, which can affect tumor immunology and patient prognosis. Understanding the structure and function of these antigens is essential for developing targeted therapies and improving patient outcomes in transfusion medicine and oncology.

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Blood Group AB antigen Antibody (Z5H-2/Z2A) References:

1. Effect of carbamylation of lysine epsilon-amino groups on the activity of blood group specific glycoproteins.  |  Springer, GF., et al. 1975. Immunol Commun. 4: 553-64. PMID: 57092
2. Biochemistry and Genetics of the ABO, Lewis, and P blood group systems.  |  Watkins, WM. 1980. Adv Hum Genet. 10: 1-136, 379-85. PMID: 6156588
3. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens.  |  Borén, T., et al. 1993. Science. 262: 1892-5. PMID: 8018146
4. Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity.  |  Appelmelk, BJ., et al. 1996. Infect Immun. 64: 2031-40. PMID: 8675304
5. Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging.  |  Ilver, D., et al. 1998. Science. 279: 373-7. PMID: 9430586

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Blood Group AB antigen Antibody (Z5H-2/Z2A) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Blood Group AB antigen Antibody (Z5H-2/Z2A) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Blood Group AB antigen Antibody (Z5H-2/Z2A) Specifications

Alternate Product Name: Blood Group AB antigen

Product Clone Name: Z5H-2/Z2A

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids:

Epitope Target: Blood Group AB antigen

Epitope Species: human

Product Reactivity/Detection: Blood Group AB antigen

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 100 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Blood Group AB antigen Antibody (Z5H-2/Z2A): FITC: Fluoroscein