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Blood Group A Tetrasaccharide (CAS 59957-92-5)

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Alternate Names:
GalNAca1-3(Fuca1-2)Galb1-4Glc
CAS Number:
59957-92-5
Purity:
≥90%
Molecular Weight:
691.63
Molecular Formula:
C26H45NO20
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Blood Group A Tetrasaccharide, a tetrasaccharide antigen found on the surface of red blood cells in individuals with blood type A, has garnered significant attention in scientific research for its role in blood group antigenicity and carbohydrate recognition processes. This tetrasaccharide structure consists of four sugar units, namely N-acetyl-D-galactosamine, D-galactose, L-fucose, and N-acetyl-D-glucosamine, arranged in a specific configuration. Researchers have extensively studied the interactions of Blood Group A Tetrasaccharide with carbohydrate-binding proteins, such as lectins and antibodies, to explain the molecular basis of blood group antigen recognition and immune responses. Moreover, this tetrasaccharide has been employed as a model system in glycobiology studies to investigate carbohydrate-protein interactions, glycan biosynthesis pathways, and enzymatic modifications involved in blood group antigen expression. By elucidating the structural determinants and molecular recognition patterns of Blood Group A Tetrasaccharide, researchers aim to deepen our understanding of immune recognition processes, glycan-mediated cell adhesion, and signaling events. Furthermore, insights gained from studying this tetrasaccharide antigen contribute to the development of novel diagnostic tools, glycoengineering strategies, and interventions targeting carbohydrate-mediated biological processes. Through interdisciplinary collaborations and advanced analytical techniques, researchers continue to unravel the complex roles of Blood Group A Tetrasaccharide in health and disease, driving advancements in glycobiology and biomedical research.


Blood Group A Tetrasaccharide (CAS 59957-92-5) References

  1. Conformational studies of blood group A and blood group B oligosaccharides using NMR residual dipolar couplings.  |  Azurmendi, HF. and Bush, CA. 2002. Carbohydr Res. 337: 905-15. PMID: 12007473
  2. Two novel decaglycosylceramides with a blood group A-active tetrasaccharide repeat in the epithelial cells of the small intestine of inbred rats.  |  Bouhours, D., et al. 1992. J Biol Chem. 267: 18533-40. PMID: 1526990
  3. Blood group antigen recognition by a Streptococcus pneumoniae virulence factor.  |  Boraston, AB., et al. 2006. J Biol Chem. 281: 35263-71. PMID: 16987809
  4. Molecular dynamics simulation of Lewis blood groups and related oligosaccharides.  |  Mukhopadhyay, C. and Bush, CA. 1991. Biopolymers. 31: 1737-46. PMID: 1793812
  5. Chemoenzymatic Synthesis of a Type 2 Blood Group A Tetrasaccharide and Development of High-throughput Assays Enables a Platform for Screening Blood Group Antigen-cleaving Enzymes.  |  Kwan, DH., et al. 2015. Glycobiology. 25: 806-11. PMID: 25964111
  6. Structural characterization of human galectin-4 C-terminal domain: elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens.  |  Bum-Erdene, K., et al. 2015. FEBS J. 282: 3348-67. PMID: 26077389
  7. Blood Group O→A Transformation by Chemical Ligation of Erythrocytes.  |  Ryzhov, IM., et al. 2019. Chembiochem. 20: 131-133. PMID: 30019804
  8. The determination of the structure of blood group oligosaccharides from fully assigned 1H-n.m.r. spectra for solutions in non-aqueous solvents.  |  Rao, BN. and Bush, CA. 1988. Carbohydr Res. 180: 111-28. PMID: 3197039
  9. The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract.  |  Wu, H., et al. 2021. PLoS Biol. 19: e3001498. PMID: 34936658
  10. The adhesive specificity of the soluble human lectin, IgE-binding protein, toward lipid-linked oligosaccharides. Presence of the blood group A, B, B-like, and H monosaccharides confers a binding activity to tetrasaccharide (lacto-N-tetraose and lacto-N-neotetraose) backbones.  |  Feizi, T., et al. 1994. Biochemistry. 33: 6342-9. PMID: 8193150

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Blood Group A Tetrasaccharide, 250 µg

sc-285031
250 µg
$600.00

Blood Group A Tetrasaccharide, 500 µg

sc-285031A
500 µg
$902.00