PRDM1/Blimp-1 Antibody (C-7): sc-398699

Blimp-1 Antibody (C-7) is a mouse monoclonal IgG3 kappa light chain antibody that detects Blimp-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Blimp-1 antibody (C-7) is available in a non-conjugated form, specifically designed for researchers seeking to study the role of Blimp-1 in B-cell differentiation. Blimp-1, also known as B lymphocyte-induced maturation protein or PRDI-BF1, is a crucial transcriptional repressor that plays a significant role in the development of plasma cells, which are the terminally differentiated forms of B-cells responsible for antibody production. Blimp-1 is predominantly located in the nucleus, where Blimp-1 acts as a master regulator of B-cell terminal differentiation, ensuring that fully activated B cells transition into plasma cells while eliminating immature or partially activated cells. Blimp-1′s nuclear localization enables direct influence on gene expression, including the upregulation of syndecan-1 and J chain, while repressing genes such as IFN-β and c-myc through interactions with histone deacetylases. Understanding Blimp-1′s function and regulatory mechanisms provides insights into the processes governing immune responses and the development of antibody-secreting cells, making Blimp-1 monoclonal antibody (C-7) an invaluable tool for studies in immunology and cell biology.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PRDM1/Blimp-1 Antibody (C-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-PRDM1/Blimp-1 Antibody (C-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PRDM1/Blimp-1 Antibody (C-7) Specifications

Alternate Product Name: PRDM1

Product Clone Name: C-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 21-57

Epitope Target: Blimp-1

Epitope Species: human

Product Reactivity/Detection: Blimp-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for PRDM1/Blimp-1 Antibody (C-7): P: Blocking Peptide, X: TransCruz Reagent

The preferred PRDM1/Blimp-1 antibody is PRDM1/Blimp-1 Antibody (6D3): sc-47732.