Molecular structure of Bleomycin Sulfate, CAS Number: 9041-93-4
Bleomycin Sulfate (CAS 9041-93-4)
See product citations (38)
Alternate Names:
Bleomycin Sulfate also known as Blenoxane; Blexane; Bleo; bleomycin sulfate (salt)
Application:
Bleomycin Sulfate is a glycopeptide antibiotic produced by bacterium S. verticillus which is capable of cleaving DNA backbone
CAS Number:
9041-93-4
Purity:
≥90%
Molecular Weight:
1512
Molecular Formula:
C55H84N17O21S3•H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bleomycin sulfate is the sulfate salt of a complex chemical. Bleomycin Sulfate approximates metals such as Fe(II) which then coordinate dioxygen to generate the active species. This Bleomycin-metal-dioxygen species is capable of inducing oxidative cleavage of the DNA backbone, leading to apoptosis. The species also degrades RNA, and has been reported to display selectivity for RNA over DNA. Bleomycin Sulfate can achieve this by chelating metal ions, producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
Bleomycin Sulfate (CAS 9041-93-4) References
- Cleavage of tRNA by Fe(II)-bleomycin. | Hüttenhofer, A., et al. 1992. J Biol Chem. 267: 24471-5. PMID: 1280260
- The role of redox-active metals in the mechanism of action of bleomycin. | Petering, DH., et al. 1990. Chem Biol Interact. 73: 133-82. PMID: 1690086
- A new twist in cellular resistance to the anticancer drug bleomycin-A5. | Aouida, M. and Ramotar, D. 2010. Curr Drug Metab. 11: 595-602. PMID: 20812903
- Toxicities associated with bleomycin. | Fyfe, AJ. and McKay, P. 2010. J R Coll Physicians Edinb. 40: 213-5. PMID: 21127762
- Comparative analysis of the biosynthetic gene clusters and pathways for three structurally related antitumor antibiotics: bleomycin, tallysomycin, and zorbamycin. | Galm, U., et al. 2011. J Nat Prod. 74: 526-36. PMID: 21210656
- What has happened to VBM (vinblastine, bleomycin, and methotrexate) chemotherapy for early-stage Hodgkin lymphoma? | Gobbi, PG. and Federico, M. 2012. Crit Rev Oncol Hematol. 82: 18-24. PMID: 21592816
- Modeling pulmonary fibrosis with bleomycin. | Mouratis, MA. and Aidinis, V. 2011. Curr Opin Pulm Med. 17: 355-61. PMID: 21832918
- Case of bleomycin-induced scleroderma. | Inaoki, M., et al. 2012. J Dermatol. 39: 482-4. PMID: 21955042
- Revisiting bleomycin from pathophysiology to safe clinical use. | Froudarakis, M., et al. 2013. Crit Rev Oncol Hematol. 87: 90-100. PMID: 23312772
- Effect of local bleomycin sulfate application on seroma formation in a rat mastectomy and axillary lymph node dissection model. | Eser, M., et al. 2014. Eur J Pharmacol. 723: 375-80. PMID: 24231620
- Balancing risks and benefits of therapy for patients with favorable-risk limited-stage Hodgkin lymphoma: the role of doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy alone. | Hay, AE. and Meyer, RM. 2014. Hematol Oncol Clin North Am. 28: 49-63. PMID: 24287067
- Intralesional Bleomycin for Orbital Lymphatic Malformations: Comparison of Clinical Versus Radiologic Regression by Volumetric Analysis. | Dave, TV., et al. Ophthalmic Plast Reconstr Surg. 37: S85-S91. PMID: 32976330
- Carcinogenicity of bleomycin sulfate and peplomycin sulfate after repeated subcutaneous application to rats. | Habs, M. and Schmähl, D. 1984. Oncology. 41: 114-9. PMID: 6200809
- Bleomycin sulfate-induced micronuclei in human, rat, and mouse peripheral blood lymphocytes. | Erexson, GL., et al. 1995. Environ Mol Mutagen. 25: 31-6. PMID: 7533077
- On the chemistry of RNA degradation by Fe.bleomycin. | Holmes, CE., et al. 1997. Bioorg Med Chem. 5: 1235-48. PMID: 9222517
Inhibitor of:
AI481877, BAT5, Borealin, C11orf82, C6orf167, CCDC79, Clb5, CUL-5, Dim1, DinB, DNA Ligase I, DNA Ligase III, FAM64A, HELIC1, hSNF2H, I-SceI, Nei-like DNA glycosylase (NEIL), OTTMUSG00000016781, PLK4, Psf2, RecQL4, REPIN1, RNA pol α, RNase HII-A, RPA 34 kDa subunit, scc-112_Pds5a, SMC6, TDE1, TDP2, TEX19, Txl-2, XRCC1, and XRCC2.Activator of:
ALKBH2, ANKRD41, Artemis, ASF1A, Azi2, BLM hydrolase, Borealin, BTBD12, C17orf53, CCDC6, CENP-H, CENP-S, Centrin-1, DDB2, DNA pol α, DNA2L, Eme1, ERCC1, FANCA, FASP1, Filamin β, GADD 45γ, HORMAD1, KLKb2, LRWD1, MBD4, Mec3, MSH3_Msh3, Nek1, NOP16, NSE1, p53R2, PRP19, RAP80, RecQL4, Reg lllγ, REV1, RFC1, RFC2, RFC4, Ribosomal Protein S3, RNF168, RT1-EC2, SerpinA1c, Sfta2, Slc4a11, SMC1β, SPATA22, SSX4, TEX11, UBE2T, WDHD1, WFDC10A, WFDC10B, WFDC11, WFDC12, WFDC13, WFDC3, and WFDC5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bleomycin Sulfate, 10 mg | sc-200134 | 10 mg | $210.00 | |||
Bleomycin Sulfate, 50 mg | sc-200134A | 50 mg | $624.00 | |||
Bleomycin Sulfate, 100 mg | sc-200134B | 100 mg | $1040.00 | |||
Bleomycin Sulfate, 500 mg | sc-200134C | 500 mg | $2913.00 |