Bleomycin A5 hydrochloride (CAS 55658-47-4)
QUICK LINKS
Bleomycin A5 hydrochloride is a chemical compound that functions as a DNA-cleaving agent. It acts by binding to DNA and inducing strand scission through the production of free radicals. Bleomycin A5 Hydrochloride′s mechanism of action involves the generation of superoxide and hydroxyl radicals, which cause oxidative damage to the DNA molecule. This results in the breaking of the DNA backbone, leading to the inhibition of DNA replication and transcription. Bleomycin A5 hydrochloride targets guanine and cytosine bases in the DNA sequence, leading to the disruption of the genetic code. Bleomycin A5 Hydrochloride′s ability to induce DNA damage may be a useful for studying DNA repair mechanisms and investigating the effects of DNA damage on cellular processes. Its role in experimental applications involves elucidating the molecular mechanisms of DNA damage and repair, as well as exploring its potential applications in various research fields.
Bleomycin A5 hydrochloride (CAS 55658-47-4) References
- Frequency of arteriovenous shunts in hepatic cavernous hemangiomas in adults as seen on selective arteriography and postembolization radiography. | Ouyang, Y., et al. 2001. Cardiovasc Intervent Radiol. 24: 161-7. PMID: 11443403
- [Direct site-specific cleavage of double-stranded DNA by conjugates of bleomycin A5 with triplex-forming oligonucleotide]. | Pavlova, AS., et al. 2009. Bioorg Khim. 35: 215-25. PMID: 19537173
- Percutaneous sclerotherapy of massive venous malformations of the face and neck using fibrin glue combined with OK-432 and pingyangmycin. | Chen, WL., et al. 2010. Head Neck. 32: 467-72. PMID: 19672870
- Analysis of thermochemotherapy-induced apoptosis and the protein expressions of Bcl-2 and Bax in maxillofacial squamous cell carcinomas. | Zhao, J., et al. 2011. Med Oncol. 28 Suppl 1: S354-9. PMID: 21104343
- Pingyangmycin-regulated expressions of adhesion molecules in human venous malformation endothelial cells. | Jia, Y., et al. 2012. J Huazhong Univ Sci Technolog Med Sci. 32: 760-766. PMID: 23073810
- Bleomycin loaded magnetite nanoparticles functionalized by polyacrylic acid as a new antitumoral drug delivery system. | Xu, Y., et al. 2013. Biomed Res Int. 2013: 462589. PMID: 23998124
- Bariatric embolization of the gastric arteries for the treatment of obesity. | Weiss, CR., et al. 2015. J Vasc Interv Radiol. 26: 613-24. PMID: 25777177
- Transcatheter Arterial Embolization Alone for Giant Hepatic Hemangioma. | Sun, JH., et al. 2015. PLoS One. 10: e0135158. PMID: 26287964
- Dexamethasone reduces serum level of IL-17 in Bleomycin-A5-induced rats model of pulmonary fibrosis. | Wang, A., et al. 2018. Artif Cells Nanomed Biotechnol. 46: 783-787. PMID: 28608724
- Effects of sclerosing agents on head and neck hemangiomas: A systematic review. | Stuepp, RT., et al. 2019. J Clin Exp Dent. 11: e1033-e1044. PMID: 31700578
- Rationale and Preclinical Data Supporting Bariatric Arterial Embolization. | Fu, Y. and Kraitchman, DL. 2020. Tech Vasc Interv Radiol. 23: 100656. PMID: 32192641
- Synthesis of bleomycin A5 oligonucleotide derivatives and site-specific cleavage of the DNA target. | Zarytova, VF., et al. 1993. Bioconjug Chem. 4: 189-93. PMID: 7686774
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bleomycin A5 hydrochloride, 1 mg | sc-394413 | 1 mg | $180.00 |