Molecular structure of (+)-Blebbistatin, CAS Number: 1177356-70-5
(+)-Blebbistatin (CAS 1177356-70-5)
Application:
(+)-Blebbistatin is a useful negative control for the active enantiomer
CAS Number:
1177356-70-5
Purity:
≥98%
Molecular Weight:
292.3
Molecular Formula:
C18H16N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
The inactive enantiomer of (±)-Blebbistatin. It is useful as a negative control for the active enantiomer, (−)-Blebbistatin.
(+)-Blebbistatin (CAS 1177356-70-5) References
- Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. | Straight, AF., et al. 2003. Science. 299: 1743-7. PMID: 12637748
- A single class II myosin modulates T cell motility and stopping, but not synapse formation. | Jacobelli, J., et al. 2004. Nat Immunol. 5: 531-8. PMID: 15064761
- Mechanism of blebbistatin inhibition of myosin II. | Kovács, M., et al. 2004. J Biol Chem. 279: 35557-63. PMID: 15205456
- Blebbistatin and blebbistatin-inactivated myosin II inhibit myosin II-independent processes in Dictyostelium. | Shu, S., et al. 2005. Proc Natl Acad Sci U S A. 102: 1472-7. PMID: 15671182
- Myosin II ATPase activity mediates the long-term potentiation-induced exodus of stable F-actin bound by drebrin A from dendritic spines. | Mizui, T., et al. 2014. PLoS One. 9: e85367. PMID: 24465547
- Real-time two- and three-dimensional imaging of monocyte motility and navigation on planar surfaces and in collagen matrices: roles of Rho. | Bzymek, R., et al. 2016. Sci Rep. 6: 25016. PMID: 27122054
- P2X7 as a scavenger receptor for innate phagocytosis in the brain. | Gu, BJ. and Wiley, JS. 2018. Br J Pharmacol. 175: 4195-4208. PMID: 30098011
- Tau interactome analyses in CRISPR-Cas9 engineered neuronal cells reveal ATPase-dependent binding of wild-type but not P301L Tau to non-muscle myosins. | Wang, X., et al. 2019. Sci Rep. 9: 16238. PMID: 31700063
- NMMHC IIA triggers neuronal autophagic cell death by promoting F-actin-dependent ATG9A trafficking in cerebral ischemia/reperfusion. | Wang, G., et al. 2020. Cell Death Dis. 11: 428. PMID: 32513915
- Pinching the cortex of live cells reveals thickness instabilities caused by myosin II motors. | Laplaud, V., et al. 2021. Sci Adv. 7: PMID: 34215576
- Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism. | Han, L., et al. 2023. Nat Cell Biol. 25: 1033-1046. PMID: 37264180
Inhibitor of:
ATPase, and MYH7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(+)-Blebbistatin, 1 mg | sc-311293 | 1 mg | $218.00 |