Molecular structure of Blasticidin S Hydrochloride, CAS Number: 3513-03-9
Blasticidin S Hydrochloride (CAS 3513-03-9)
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Alternate Names:
Blasticidin S Hydrochloride also known as BLASTICIDIN S HCL; BLASTICIDIN S HYDROCHLORIDE; BLASTICIDIN S, HYDROCHLORIDE, STREPTOMYCES; GRISEOCHROMOGENES; blasticidin S
Application:
Blasticidin S Hydrochloride is an antibiotic inhibiting protein synthesis and belongs to a group of cytosine amino nucleoside antibiotics
CAS Number:
3513-03-9
Purity:
≥98%
Molecular Weight:
458.9
Molecular Formula:
C17H26N8O5•HCl
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Blasticidin S Hydrochloride, like puromycin (sc-205821), belongs to a group of cytosine amino nucleoside antibiotics. Blasticidin S is isolated from Streptomyces griseochromogenes and inhibits protein synthesis in both prokaryotic and eukaryotic cells, Blasticidin S Hydrochloride acts quickly by inhibiting peptide bond formation by the ribosome. The blasticidin S resistance gene (BSR), found in Bacillus cereus K55-S1, has been used in multiple studies for its use as a selective compound. Resistance is conferred by expression of one of two Blasticidin S deaminase genes: BSD from Aspergillus terreus or bsr from Bacillus cereus. These deaminases convert Blasticidin S to a nontoxic deaminohydroxy derivative. Blasticidin S Hydrochloride is used as a selection agent for transformed cells that contain the resistance genes bls, bsr or BSD.
Blasticidin S Hydrochloride (CAS 3513-03-9) References
- Blasticidin S, a new antibiotic. | TAKEUCHI, S., et al. 1958. J Antibiot (Tokyo). 11: 1-5. PMID: 13525246
- Total synthesis of (+)-blasticidin s. | Ichikawa, Y., et al. 2004. Chemistry. 10: 3241-51. PMID: 15224333
- Molecular cloning and characterization of gene encoding novel puromycin-inactivating enzyme from blasticidin S-producing Streptomyces morookaensis. | Nishimura, M., et al. 2006. J Biosci Bioeng. 101: 63-9. PMID: 16503293
- Blasticidin S-resistance gene (bsr): a novel selectable marker for mammalian cells. | Izumi, M., et al. 1991. Exp Cell Res. 197: 229-33. PMID: 1720391
- A blasticidin S-resistant Plasmodium falciparum mutant with a defective plasmodial surface anion channel. | Hill, DA., et al. 2007. Proc Natl Acad Sci U S A. 104: 1063-8. PMID: 17213308
- The blasticidin S resistance gene (bsr) selectable in a single copy state in the Bacillus subtilis chromosome. | Itaya, M., et al. 1990. J Biochem. 107: 799-801. PMID: 2118136
- Gene networking and inflammatory pathway analysis in a JMJD3 knockdown human monocytic cell line. | Das, ND., et al. 2012. Cell Biochem Funct. 30: 224-32. PMID: 22252741
- Inhibition of STAT1 sensitizes renal cell carcinoma cells to radiotherapy and chemotherapy. | Zhu, H., et al. 2012. Cancer Biol Ther. 13: 401-7. PMID: 22262126
- Expression of the blasticidin S deaminase gene (bsr) in tobacco: fungicide tolerance and a new selective marker for transgenic plants. | Kamakura, T., et al. 1990. Mol Gen Genet. 223: 332-4. PMID: 2250657
- ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes. | Dixen, K., et al. 2013. Obesity (Silver Spring). 21: 516-24. PMID: 23404793
- Effects of miR-19b overexpression on proliferation, differentiation, apoptosis and Wnt/β-catenin signaling pathway in P19 cell model of cardiac differentiation in vitro. | Qin, DN., et al. 2013. Cell Biochem Biophys. 66: 709-22. PMID: 23443808
- Crystal and molecular structure of the antibiotic blasticidin S hydrochloride pentahydrate. | Swaminathan, V., et al. 1981. Biochim Biophys Acta. 655: 335-41. PMID: 7284390
- Blasticidin S deaminase gene from Aspergillus terreus (BSD): a new drug resistance gene for transfection of mammalian cells. | Kimura, M., et al. 1994. Biochim Biophys Acta. 1219: 653-9. PMID: 7948022
- Induction of cholinergic differentiation with neurite sprouting by de novo biosynthesis and expression of GD3 and b-series gangliosides in Neuro2a cells. | Kojima, N., et al. 1994. J Biol Chem. 269: 30451-6. PMID: 7982960
- Cloning of the blasticidin S deaminase gene (BSD) from Aspergillus terreus and its use as a selectable marker for Schizosaccharomyces pombe and Pyricularia oryzae. | Kimura, M., et al. 1994. Mol Gen Genet. 242: 121-9. PMID: 8159161
Inhibitor of:
κ-Actin, ACTBL2, C14orf21, CES4, CLCA4_Clac4, CLTCL1, CSHL1, Cyclon, CYP4F12, CYP4F8, CYP4V3, DDX26B, DGCR6L, EF-1δP1, EG621697, Elastase-2B, ENY2, Ermin, ERVK6, FABP5L1, FABP5L2, FABP5L7, FAM86B1, FLJ44635, GMEB-1, GSTA5, hCG_15200, HGSNAT, HSPC105, HSPC152, ILPIP, INS-IGF2, KRTAP10, KRTAP5, L1TD1, Liprin α3, LOC100040722, LOC646736, LRRC39, MiRP1, Ribosomal Protein L23, Ribosomal Protein L30, Ribosomal Protein LP0, Ribosomal Protein S11, Ribosomal Protein S15, Ribosomal Protein S18, Ribosomal Protein S21, Ribosomal Protein S25, RP23-221K3.2, RPL24, RPL39, Sup35, Synaptotagmin VI, TARSL2, TCEB1P3, TFIIH p44L, TMEM55B, and UBE2G1.Activator of:
DDX1, DDX51, QM, Ribosomal Protein L27a, Ribosomal Protein L32, Ribosomal Protein L36a, Ribosomal Protein S17, and Ribosomal Protein S23.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Blasticidin S Hydrochloride, 25 mg | sc-204655A | 25 mg | $360.00 | |||
Blasticidin S Hydrochloride, 100 mg | sc-204655 | 100 mg | $475.00 |