Molecular structure of Bisindolylmaleimide X hydrochloride, CAS Number: 145317-11-9
Bisindolylmaleimide X hydrochloride (CAS 145317-11-9)
Alternate Names:
Ro 31-8425; BIM X
Application:
Bisindolylmaleimide X hydrochloride is a selective inhibitor of PKC, also inhibits Cdk2 and GSK-3β
CAS Number:
145317-11-9
Purity:
≥98%
Molecular Weight:
460.96
Molecular Formula:
C26H24N4O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bisindolylmaleimide X hydrochloride is a compound that functions as a potent and selective inhibitor of protein kinase C (PKC). It exerts its mechanism of action by competitively binding to the ATP-binding site of PKC, thereby preventing the phosphorylation of downstream substrates. This inhibition of PKC activity leads to the disruption of various cellular processes, including cell proliferation, differentiation, and apoptosis. Bisindolylmaleimide X hydrochloride may act to modulate intracellular signaling pathways involved in the regulation of gene expression and cell cycle progression. Its ability to specifically target PKC isoforms may be useful for investigating the role of PKC in various cellular functions and for elucidating the molecular mechanisms underlying PKC-related diseases.
Bisindolylmaleimide X hydrochloride (CAS 145317-11-9) References
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- Effects of phospholipase D during cultured osteoblast mineralization and bone formation. | Abdallah, D., et al. 2019. J Cell Biochem. 120: 5923-5935. PMID: 30320913
- Role of PKC and ERK Signaling in Epidermal Blistering and Desmosome Regulation in Pemphigus. | Egu, DT., et al. 2019. Front Immunol. 10: 2883. PMID: 31867019
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Inhibitor of:
Cdk2, Enzyme, GM130, nephrocystin, PKC, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bisindolylmaleimide X hydrochloride, 1 mg | sc-221368 | 1 mg | $120.00 | |||
Bisindolylmaleimide X hydrochloride, 5 mg | sc-221368A | 5 mg | $400.00 |