Molecular structure of Bisindolylmaleimide VIII, CAS Number: 138516-31-1
Bisindolylmaleimide VIII (CAS 138516-31-1)
See product citations (6)
Alternate Names:
Ro 31-7549 acetate
Application:
Bisindolylmaleimide VIII is a selective PKC inhibitor
CAS Number:
138516-31-1
Purity:
≥98%
Molecular Weight:
458.60
Molecular Formula:
C24H22N4O2•C2H4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bisindolylmaleimide VIII is a selective PKC (protein kinase C) inhibitor, with observed binding activity to dystrophia myotonica protein kinase (DMPK). Bisindolylmaleimide VIII is suggested as being slightly more specific for PKC alpha over PKC beta, PKC gamma, and PKC epsilon isozymes (IC50 = 53, 195, 213, and 275 respectively). The compound may act to improve DR5-mediated apoptosis through the MKK4/JNK/p38 kinase. When bisindolylmaleimide VIII is combined with TRA-8 it can activate c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase. Bisindolylmaleimide VIII enhance Fas-mediated apoptosis in both human astrocytoma 1321N1 cells and in Molt-4T cells.
Bisindolylmaleimide VIII (CAS 138516-31-1) References
- Partial synergy of bisindolylmaleimide with apoptotic stimulus in antigen-specific T cells--implications for multiple sclerosis. | Wendling, U., et al. 2000. J Neuroimmunol. 103: 69-75. PMID: 10674991
- Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways. | Ohtsuka, T. and Zhou, T. 2002. J Biol Chem. 277: 29294-303. PMID: 12034736
- Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC. | Wen, HC., et al. 2003. Cell Signal. 15: 37-45. PMID: 12401518
- The PKC gene module: molecular biosystematics to resolve its T cell functions. | Baier, G. 2003. Immunol Rev. 192: 64-79. PMID: 12670396
- Sensitizing antigen-specific CD8+ T cells for accelerated suicide causes immune incompetence. | Wasem, C., et al. 2003. J Clin Invest. 111: 1191-9. PMID: 12697738
- The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) provokes a prolonged morphologic response and ERK activation in Tsc2-null renal tumor cells. | Kolb, TM. and Davis, MA. 2004. Toxicol Sci. 81: 233-42. PMID: 15178807
- Different signaling pathways involved in glucose- and cell swelling-induced insulin secretion by rat pancreatic islets in vitro. | Bacová, Z., et al. 2005. Cell Physiol Biochem. 16: 59-68. PMID: 16121034
- Increase of Fas-induced apoptosis by inhibition of extracellular phosphorylation of Fas receptor in Jurkat cell line. | Lautrette, C., et al. 2006. Apoptosis. 11: 1195-204. PMID: 16699962
- Structure of dystrophia myotonica protein kinase. | Elkins, JM., et al. 2009. Protein Sci. 18: 782-91. PMID: 19309729
- Mechanism of ethanol-induced insulin secretion from INS-1 and INS-1E tumor cell lines. | Hafko, R., et al. 2009. Cell Physiol Biochem. 24: 441-50. PMID: 19910684
- A single amino acid residue controls Ca2+ signaling by an octopamine receptor from Drosophila melanogaster. | Hoff, M., et al. 2011. FASEB J. 25: 2484-91. PMID: 21478261
- Nrf2-mediated adaptive response to cadmium-induced toxicity involves protein kinase C delta in human 1321N1 astrocytoma cells. | Lawal, AO. and Ellis, EM. 2011. Environ Toxicol Pharmacol. 32: 54-62. PMID: 21787730
- Caffeoylserotonin protects human keratinocyte HaCaT cells against H2 O2 -induced oxidative stress and apoptosis through upregulation of HO-1 expression via activation of the PI3K/Akt/Nrf2 pathway. | Nguyen, CN., et al. 2013. Phytother Res. 27: 1810-8. PMID: 23418094
- PKCα mediated by the PI3K/Akt-FOXA1 cascade facilitates cypermethrin-induced hyperthyroidism. | Ha, M., et al. 2021. Sci Total Environ. 757: 143727. PMID: 33250241
- Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases. | Zhou, T., et al. 1999. Nat Med. 5: 42-8. PMID: 9883838
Inhibitor of:
cPKC γ, PKC, PKC beta, and Ser/Thr Protein Kinase.Activator of:
ERK 5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bisindolylmaleimide VIII, 1 mg | sc-24005 | 1 mg | $48.00 |