Bisindolylmaleimide VII (CAS 137592-47-3)
QUICK LINKS
Bisindolylmaleimide VII functions as a potent and selective inhibitor of protein kinase C (PKC). It exerts its mechanism of action by competitively binding to the ATP-binding site of PKC, thereby preventing the phosphorylation of downstream substrates. This inhibition of PKC activity may modulate various cellular processes, including cell proliferation, differentiation, and apoptosis. By targeting PKC, Bisindolylmaleimide VII can be used to investigate the specific roles of PKC isoforms in signal transduction pathways and cellular functions. Its ability to selectively inhibit PKC may be useful in studying the molecular mechanisms underlying PKC-mediated signaling in experimental applications. Bisindolylmaleimide VII′s mechanism of action at the molecular level provides insights into the regulatory functions of PKC in cellular processes, contributing to the understanding of intracellular signaling pathways.
Bisindolylmaleimide VII (CAS 137592-47-3) References
- Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. | Davis, PD., et al. 1992. J Med Chem. 35: 177-84. PMID: 1732526
- Activation of kainate receptors controls the number of functional glutamatergic synapses in the area CA1 of rat hippocampus. | Vesikansa, A., et al. 2007. J Physiol. 583: 145-57. PMID: 17569736
- IP3 receptor-dependent Ca2+ release modulates excitation-contraction coupling in rabbit ventricular myocytes. | Domeier, TL., et al. 2008. Am J Physiol Heart Circ Physiol. 294: H596-604. PMID: 18055509
- The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. | Toullec, D., et al. 1991. J Biol Chem. 266: 15771-81. PMID: 1874734
- Regulation of nuclear factor of activated T cells (NFAT) in vascular endothelial cells. | Rinne, A., et al. 2009. J Mol Cell Cardiol. 47: 400-10. PMID: 19540841
- Microbial alkaloid staurosporine induces formation of nanometer-wide membrane tubular extensions (cytonemes, membrane tethers) in human neutrophils. | Galkina, SI., et al. 2010. Cell Adh Migr. 4: 32-8. PMID: 20009568
- Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels. | Yudin, Y., et al. 2011. J Physiol. 589: 6007-27. PMID: 22005680
- Peripheral TGF-β1 signaling is a critical event in bone cancer-induced hyperalgesia in rodents. | Xu, Q., et al. 2013. J Neurosci. 33: 19099-111. PMID: 24305807
- Axonal Kainate Receptors Modulate the Strength of Efferent Connectivity by Regulating Presynaptic Differentiation. | Sakha, P., et al. 2016. Front Cell Neurosci. 10: 3. PMID: 26834558
- FIKK Kinase, a Ser/Thr Kinase Important to Malaria Parasites, Is Inhibited by Tyrosine Kinase Inhibitors. | Lin, BC., et al. 2017. ACS Omega. 2: 6605-6612. PMID: 30023525
- Human B cells infected by Trypanosoma cruzi undergo F-actin disruption and cell death via caspase-7 activation and cleavage of phospholipase Cγ1. | Dos Santos, MA., et al. 2020. Immunobiology. 225: 151904. PMID: 31959539
- A cell-based drug delivery platform for treating central nervous system inflammation. | Levy, O., et al. 2021. J Mol Med (Berl). 99: 663-671. PMID: 33398468
- Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. | Fabre, S., et al. 1993. Bioorg Med Chem. 1: 193-6. PMID: 8081852
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bisindolylmaleimide VII, 1 mg | sc-202504 | 1 mg | $36.00 | |||
Bisindolylmaleimide VII, 5 mg | sc-202504A | 5 mg | $153.00 |