Bisindolylmaleimide V (CAS 113963-68-1)
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Bisindolylmaleimide V is used as a negative control for the PKC (protein kinase C)-inhibitory activity. Bisindolylmaleimide V, also known as BIM V, exhibits weak inhibition against protein kinase C (PKC) with an IC50 value exceeding 100 µM. Despite its limited potency as a PKC inhibitor, Bisindolylmaleimide V effectively impedes the activation of in vivo mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) with an IC50 value of 8 µM. Functioning as a negative control for PKC inhibitors, Bisindolylmaleimide V serves as an inhibitor of S6K and a safeguard against necrosis. It stands as a cell-permeable compound, valuable for protein kinase C inhibition studies, showcasing an IC50 greater than 100 µM. Its capacity to halt the activation of p70s6k/p85s6k in vivo is demonstrated with an IC50 of 8 µM.
Bisindolylmaleimide V (CAS 113963-68-1) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bisindolylmaleimide V, 1 mg | sc-202080 | 1 mg | $49.00 | |||
Bisindolylmaleimide V, 5 mg | sc-202080A | 5 mg | $168.00 |