Molecular structure of Bisindolylmaleimide III, Hydrochloride
Bisindolylmaleimide III, Hydrochloride
Application:
Bisindolylmaleimide III, Hydrochloride is a potent, cell permeable, and selective PKC inhibitor
Purity:
≥95%
Molecular Weight:
420.9
Molecular Formula:
C23H20N4O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A potent, cell permeable, and selective inhibitor of protein kinase C (IC50 = 26 nM). It may inhibit protein kinase A at much higher concentrations (IC50 = 500 nM).
Bisindolylmaleimide III, Hydrochloride References
- The vasoactive peptide urotensin II stimulates spontaneous release from frog motor nerve terminals. | Brailoiu, E., et al. 2003. Br J Pharmacol. 138: 1580-8. PMID: 12721114
- Mechanosensitive synoviocytes: a Ca2+ -PKCalpha-MAP kinase pathway contributes to stretch-induced hyaluronan synthesis in vitro. | Momberger, TS., et al. 2006. Matrix Biol. 25: 306-16. PMID: 16567084
- Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. | Davis, PD., et al. 1992. J Med Chem. 35: 177-84. PMID: 1732526
- The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. | Toullec, D., et al. 1991. J Biol Chem. 266: 15771-81. PMID: 1874734
- Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. | Fabre, S., et al. 1993. Bioorg Med Chem. 1: 193-6. PMID: 8081852
Inhibitor of:
Enzyme, MSK1, p70 S6 Kinase, PKA, Rsk-2, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bisindolylmaleimide III, Hydrochloride, 250 µg | sc-311291 | 250 µg | $150.00 | |||
Bisindolylmaleimide III, Hydrochloride, 1 mg | sc-311291A | 1 mg | $400.00 |