Molecular structure of Bisindolylmaleimide III, CAS Number: 137592-43-9
Bisindolylmaleimide III (CAS 137592-43-9)
See product citations (2)
Alternate Names:
BIM III
Application:
Bisindolylmaleimide III is a potent and selective inhibitor of PKC
CAS Number:
137592-43-9
Purity:
≥96%
Molecular Weight:
384.43
Molecular Formula:
C23H20N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bisindolylmaleimide III is a potent and selective inhibitor of PKC (protein kinase C). Bisindolylmaleimide III is an inhibitor of PDK1 and PKA.
Bisindolylmaleimide III (CAS 137592-43-9) References
- Activation of protein kinase C alpha enhances human growth hormone-binding protein release. | Saito, Y., et al. 1998. Mol Cell Endocrinol. 146: 197-205. PMID: 10022777
- Role of ecto-kinase in phorbol ester-enhanced growth hormone-binding protein release from human IM-9 cells. | Saito, Y., et al. 1999. Mol Cell Endocrinol. 152: 65-72. PMID: 10432224
- Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors. | Brehmer, D., et al. 2004. Mol Cell Proteomics. 3: 490-500. PMID: 14769951
- Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. | Davis, PD., et al. 1992. J Med Chem. 35: 177-84. PMID: 1732526
- Bisindolylmaleimide IX facilitates extrinsic and initiates intrinsic apoptosis in TNF-alpha-resistant human colon adenocarcinoma COLO 205 cells. | Pajak, B., et al. 2008. Apoptosis. 13: 509-22. PMID: 18347986
- An immuno-chemo-proteomics method for drug target deconvolution. | Saxena, C., et al. 2008. J Proteome Res. 7: 3490-7. PMID: 18590316
- The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. | Toullec, D., et al. 1991. J Biol Chem. 266: 15771-81. PMID: 1874734
- Capture of drug targets from live cells using a multipurpose immuno-chemo-proteomics tool. | Saxena, C., et al. 2009. J Proteome Res. 8: 3951-7. PMID: 19537828
- CALHM1 controls the Ca²⁺-dependent MEK, ERK, RSK and MSK signaling cascade in neurons. | Dreses-Werringloer, U., et al. 2013. J Cell Sci. 126: 1199-206. PMID: 23345406
- Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. | Fabre, S., et al. 1993. Bioorg Med Chem. 1: 193-6. PMID: 8081852
Inhibitor of:
Enzyme, PDK1, PKA, PKC, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bisindolylmaleimide III, 1 mg | sc-221367 | 1 mg | $74.00 | |||
Bisindolylmaleimide III, 5 mg | sc-221367A | 5 mg | $224.00 |