Date published: 2026-4-12

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Bisindolylmaleimide II (CAS 137592-45-1)

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Alternate Names:
2-(1-[2-(1-Methylpyrrolidino)ethyl]-1H-indol-3-yl-3-(1H-indol-3-yl)maleimide
Application:
Bisindolylmaleimide II is an inhibitor of PKC and PDK1
CAS Number:
137592-45-1
Purity:
≥97% (mixture of two isomers)
Molecular Weight:
438.5
Molecular Formula:
C27H26N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Bisindolylmaleimide II (BIM-II) is a small molecule inhibitor that targets protein kinases, serving as useful for investigating cellular processes. Its extensive laboratory research has deepened our understanding of its properties and potential applications. Bisindolylmaleimide II belongs to the bisindolylmaleimide (BIM) family, a significant group of structurally related compounds. This compound exhibits a diverse array of biological activities, including the inhibition of protein kinases, suppression of cell proliferation, and promotion of apoptosis. Bisindolylmaleimide II binds to and hampers the activity of several protein kinases, including protein kinase C (PKC) and MAPKs. Through the inhibition of these protein kinases, Bisindolylmaleimide II is hypothesized to influence the expression of genes involved in cell cycle progression and the regulation of cell death.


Bisindolylmaleimide II (CAS 137592-45-1) References

  1. Chromaffin cell catecholamine secretion: bisindolylmaleimide compounds exhibit novel and potent antagonist effects at the nicotinic cholinergic receptor in pheochromocytoma cells.  |  Mahata, M., et al. 2002. Mol Pharmacol. 61: 1340-7. PMID: 12021395
  2. Inhibition of protein kinases C prevents murine cytomegalovirus replication.  |  Kučić, N., et al. 2005. J Gen Virol. 86: 2153-2161. PMID: 16033962
  3. Signaling pathways of hypocretin-1 actions on pyramidal neurons in the rat prefrontal cortex.  |  Song, CH., et al. 2005. Neuroreport. 16: 1529-33. PMID: 16110284
  4. Riluzole increases glutamate uptake by cultured C6 astroglial cells.  |  Dall'Igna, OP., et al. 2013. Int J Dev Neurosci. 31: 482-6. PMID: 23777615
  5. PKC inhibition results in a Kv 1.5 + Kv β1.3 pharmacology closer to Kv 1.5 channels.  |  Macías, A., et al. 2014. Br J Pharmacol. 171: 4914-26. PMID: 24946104
  6. Dopamine modulation of transient receptor potential vanilloid type 1 (TRPV1) receptor in dorsal root ganglia neurons.  |  Chakraborty, S., et al. 2016. J Physiol. 594: 1627-42. PMID: 26563747
  7. Soluble DPP-4 up-regulates toll-like receptors and augments inflammatory reactions, which are ameliorated by vildagliptin or mannose-6-phosphate.  |  Lee, DS., et al. 2016. Metabolism. 65: 89-101. PMID: 26773932
  8. Efficient PKC inhibitor screening achieved using a quantitative CE-LIF assay.  |  Nguyen, BT., et al. 2016. Electrophoresis. 37: 3146-3153. PMID: 27783407
  9. Carnosine modulates glutamine synthetase expression in senescent astrocytes exposed to oxygen-glucose deprivation/recovery.  |  Shi, X., et al. 2017. Brain Res Bull. 130: 138-145. PMID: 28115195
  10. TRPV4 is functionally expressed in oligodendrocyte precursor cells and increases their proliferation.  |  Ohashi, K., et al. 2018. Pflugers Arch. 470: 705-716. PMID: 29569183
  11. Updates on the surface antigens of basophils: CD16 on basophils of patients with respiratory or insect venom allergy and the rejection of CD203c and CD63 externalization decoupling by bisindolylmaleimides.  |  Heneberg, P., et al. 2019. Clin Exp Allergy. 49: 54-67. PMID: 30288810
  12. Effects of a Protein Kinase Inhibitor on Sperm Motility in the Japanese Quail.  |  Matsuzaki, M., et al. 2017. J Poult Sci. 54: 73-79. PMID: 32908411
  13. IGFBP-1 hyperphosphorylation in response to nutrient deprivation is mediated by activation of protein kinase Cα (PKCα).  |  Chen, AW., et al. 2021. Mol Cell Endocrinol. 536: 111400. PMID: 34314739
  14. Hypoxia induces purinergic receptor signaling to disrupt endothelial barrier function.  |  Raghavan, S., et al. 2022. Front Physiol. 13: 1049698. PMID: 36479340

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Bisindolylmaleimide II, 1 mg

sc-221366
1 mg
$62.00

Bisindolylmaleimide II, 5 mg

sc-221366A
5 mg
$183.00