Molecular structure of Bisindolylmaleimide I, HCl, CAS Number: 176504-36-2
Bisindolylmaleimide I, HCl (CAS 176504-36-2)
See product citations (13)
Alternate Names:
3-[1-(Dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride
Application:
Bisindolylmaleimide I, HCl is a water soluble inhibitor for all known isoforms of PKC
CAS Number:
176504-36-2
Purity:
≥98%
Molecular Weight:
448.94
Molecular Formula:
C25H24N4O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bisindolylmaleimide I, HCl is a water soluble form of Bisindolylmaleimide I (sc-24003) a staurosporine (sc-3510) inspired molecule, which may act to display equally potent inhibition, but with vastly superior selectivity for all of the known isoforms of PKC (IC50 = 8-20 nM). Inhibition is competitive with respect to ATP, which suggests that Bisindolylmaleimide I occupies the ATP binding domain of the PKC isoforms. This compound has been used to selectively probe for PKC-mediated pathways for transduction of hormone, cytokine, and growth factor signals. Shown to inhibit PKC (protein kinase C) within intact platelets and T cells, Fas-mediated apoptosis, and T cell-mediated autoimmune diseases. Bisindolylmaleimide I, HCl is an inhibitor of PKC alpha, PKC beta, PKCdelta, PKC epsilon and PKC gamma.
Bisindolylmaleimide I, HCl (CAS 176504-36-2) References
- Hydrogen peroxide induces contraction and raises [Ca2+]i in canine cerebral arterial smooth muscle: participation of cellular signaling pathways. | Yang, ZW., et al. 1999. Naunyn Schmiedebergs Arch Pharmacol. 360: 646-53. PMID: 10619181
- The effects of protein kinase C and calmodulin kinase II inhibitors on vestibular compensation in the guinea pig. | Sansom, AJ., et al. 2000. Brain Res. 882: 45-54. PMID: 11056183
- Purinergic and adrenergic agonists synergize in stimulating vasopressin and oxytocin release. | Kapoor, JR. and Sladek, CD. 2000. J Neurosci. 20: 8868-75. PMID: 11102496
- Ethanol activates NFkappaB DNA binding and p56lck protein tyrosine kinase in human osteoblast-like cells. | Yao, Z., et al. 2001. Bone. 28: 167-73. PMID: 11182374
- Transmitter release from Rana pipiens vestibular hair cells via mGluRs: a role for intracellular Ca(++) release. | Hendricson, AW. and Guth, PS. 2002. Hear Res. 172: 99-109. PMID: 12361872
- The role of several kinases in mice tolerant to delta 9-tetrahydrocannabinol. | Lee, MC., et al. 2003. J Pharmacol Exp Ther. 305: 593-9. PMID: 12606657
- Protein kinase C is involved in neurokinin receptor modulation of N- and L-type Ca2+ channels in DRG neurons of the adult rat. | Sculptoreanu, A. and de Groat, WC. 2003. J Neurophysiol. 90: 21-31. PMID: 12660348
- Role of nitric oxide and protein kinase C in the tachyphylaxis to vasopressin in rat aortic rings. | Hamel, C., et al. 2005. Life Sci. 77: 1069-81. PMID: 15978263
- The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. | Toullec, D., et al. 1991. J Biol Chem. 266: 15771-81. PMID: 1874734
- The bisindolylmaleimide GF 109203X, a selective inhibitor of protein kinase C, does not inhibit the potentiating effect of phorbol ester on ethanol-induced phospholipase C-mediated hydrolysis of phosphatidylethanolamine. | Kiss, Z., et al. 1995. Biochim Biophys Acta. 1265: 93-5. PMID: 7857990
- Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. | Martiny-Baron, G., et al. 1993. J Biol Chem. 268: 9194-7. PMID: 8486620
- Protein kinase C mediates Ca2(+)-induced cardioadaptation to ischemia-reperfusion injury. | Meldrum, DR., et al. 1996. Am J Physiol. 271: R718-26. PMID: 8853396
- Ca2+-independent protein kinase C isoforms may modulate parietal cell HCl secretion. | Chew, CS., et al. 1997. Am J Physiol. 272: G246-56. PMID: 9124348
- Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases. | Zhou, T., et al. 1999. Nat Med. 5: 42-8. PMID: 9883838
Inhibitor of:
Enzyme, GSK, PKC, PKC beta, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bisindolylmaleimide I, HCl, 1 mg | sc-24004 | 1 mg | $145.00 |