Bisacodyl CAS: 603-50-9
MF: C22H19NO4
MW: 361.39
A hygroscopic diphenol.

Bisacodyl (CAS 603-50-9)

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Application: A hygroscopic diphenol
CAS Number: 603-50-9
Molecular Weight: 361.39
Molecular Formula: C22H19NO4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Bisacodyl is a hygroscopic diphenol which has been implicated in the inhibition of (Na+K)ATPase, the increase of mucosal PGE2, and the activation of adenyl cyclase in rat intestine studies.


1. Rachmilewitz, D., et al., 1980. Effects of bisacodyl on cAMP and prostaglandin E2 contents, (Na + K) ATPase, adenyl cyclase, and phosphodiesterase activities of rat intestine. Digestive diseases and sciences. 25(8): 602-8. PMID: 6249558
2. Farack, U M., et al., 1984. Mechanism of action of diphenolic laxatives: the role of adenylate cyclase and mucosal permeability. Digestion. 30(3): 191-4. PMID: 6548720

Physical State :
Solubility :
Soluble in alcohol (slightly), ether (slightly), chloroform, and acetone. Insoluble in water.
Storage :
Store at 4° C
Melting Point :
131.1-135° C
Boiling Point :
492.33° C at 760 mmHg (Predicted)
Density :
1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
GPR55: IC50 = 908.43 nM (human); Dopamine transporter: IC50 = 2.21 µM (human); KOR-1: IC50 = 2.44 µM (human); CYP2C9: IC50 = 10 µM (human); GPR35: IC50 = >32 µM (human)
Ki Data :
KOR: Ki= 975 nM (human); Dopamine transporter: Ki= 1.76 µM (human)
pK Values :
pKb: 4.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 1242
MDL Number :
EC Number :
Beilstein Registry :

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Certificate of Analysis

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Is bisacodyl, 5mg, the same as sennosides usp, 25mg?

Asked by: Minda
Thank you for your question. No, this is not a USP grade chemical.
Answered by: Tech Service
Date published: 2019-01-07
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