Date published: 2025-10-14

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BIS-Tris (CAS 6976-37-0)

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Alternate Names:
BIS-Tris is also known as Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane.
Application:
BIS-Tris is an inert, zwitterionic buffer that exhibits only a very small shift in dissociation constant
CAS Number:
6976-37-0
Purity:
>99%
Molecular Weight:
209.24
Molecular Formula:
C8H19O5N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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BIS-Tris is an inert, zwitterionic buffer that exhibits only a very small shift in dissociation constant with respect to temperature. BIS-Tris is suitable for fractionation of hemoglobin. For BIS-Tris, the useful pH range for the buffer is 5.8-7.2. BIS-Tris has a pKa of 6.5 at 25° C.


BIS-Tris (CAS 6976-37-0) References

  1. Using the flexible ligand bis(2-hydroxyethyl)amino-tris (hydroxymethyl)methane ('bis-tris') to access a family of 3d-4f Mn(III)4Ln4 complexes.  |  Khan, A., et al. 2012. Dalton Trans. 41: 8333-9. PMID: 22627968
  2. Increased glucocorticoid activation during mouse skin wound healing.  |  Tiganescu, A., et al. 2014. J Endocrinol. 221: 51-61. PMID: 24464022
  3. Acute Treatment With XMetA Activates Hepatic Insulin Receptors and Lowers Blood Glucose in Normal Mice.  |  Bedinger, DH., et al. 2015. J Cell Biochem. 116: 2109-19. PMID: 25808283
  4. Triphala Extract Suppresses Proliferation and Induces Apoptosis in Human Colon Cancer Stem Cells via Suppressing c-Myc/Cyclin D1 and Elevation of Bax/Bcl-2 Ratio.  |  Vadde, R., et al. 2015. Biomed Res Int. 2015: 649263. PMID: 26167492
  5. Cobra venom proteome and glycome determined from individual snakes of Naja atra reveal medically important dynamic range and systematic geographic variation.  |  Huang, HW., et al. 2015. J Proteomics. 128: 92-104. PMID: 26196238
  6. Electrogenerated chemiluminescence of tris(2,2' bipyridine)ruthenium(II) using common biological buffers as co-reactant, pH buffer and supporting electrolyte.  |  Kebede, N., et al. 2015. Analyst. 140: 7142-5. PMID: 26347905
  7. Neutralized chimeric DNA probe for the improvement of GC-rich RNA detection specificity on the nanowire field-effect transistor.  |  Chou, WC., et al. 2019. Sci Rep. 9: 11056. PMID: 31363139
  8. Interference of pH buffer with Pb2+-peripheral domain interactions: obstacle or opportunity?  |  Katti, S. and Igumenova, TI. 2020. Metallomics. 12: 164-172. PMID: 32051983
  9. Borate-containing background electrolytes to improve CE separation in bare capillaries.  |  Dolnik, V. 2020. Electrophoresis. 41: 1073-1080. PMID: 32233031
  10. Functional and structural characterization of PII-like protein CutA does not support involvement in heavy metal tolerance and hints at a small-molecule carrying/signaling role.  |  Selim, KA., et al. 2021. FEBS J. 288: 1142-1162. PMID: 32599651
  11. A class of low-cost alternatives to kifunensine for increasing high mannose N-linked glycosylation for monoclonal antibody production in Chinese hamster ovary cells.  |  Brantley, TJ., et al. 2021. Biotechnol Prog. 37: e3076. PMID: 32888259
  12. Polyamines Counteract Carbonate-Driven Proteasome Stalling in Alkaline Conditions.  |  Kudriaeva, AA., et al. 2020. Biomolecules. 10: PMID: 33255475
  13. An electrophoretic ion analyzer for on-site autonomous water monitoring.  |  Liu, S., et al. 2021. J Chromatogr A. 1637: 461791. PMID: 33359795

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

BIS-Tris, 100 g

sc-216088
100 g
$76.00

BIS-Tris, 500 g

sc-216088A
500 g
$195.00

BIS-Tris, 1 kg

sc-216088B
1 kg
$405.00