Molecular structure of Bis(methylthio)gliotoxin (FR-49175), CAS Number: 74149-38-5
Bis(methylthio)gliotoxin (FR-49175) (CAS 74149-38-5)
See product citations (5)
Alternate Names:
Bis(methylthio)gliotoxin (FR-49175) is known as a PAF receptor ligand.
Application:
Bis(methylthio)gliotoxin (FR-49175) is an antiphagocytic metabolite and PAF receptor ligand known to inhibit platelet aggregation.
CAS Number:
74149-38-5
Purity:
≥98%
Molecular Weight:
356.5
Molecular Formula:
C15H20N2O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bis(methylthio)gliotoxin (FR-49175) is a toxic metabolite with anthiphagocytic and immunosuppressive properties synthesized by pathogenic fungi such as Aspergillus fumigatus. Bis(methylthio)gliotoxin (FR-49175) is an analog of gliotoxin known to inhibit PAF-induced platelet aggregation and collagen-aggregation, but has no activity with arachidonic or ADP induced aggregation. Bis(methylthio)gliotoxin (FR-49175) has shown to speed up PAF hydrolysis and inhibit PAF-mediated caspase 3 activation. From guinea-pig experiments, Bis(methylthio)gliotoxin (FR-49175) is reported to Inhibit PAF-induced bronchoconstriction in vivo.
Bis(methylthio)gliotoxin (FR-49175) (CAS 74149-38-5) References
- Metal complexes of sporidesmin D and dimethylgliotoxin, investigated by electrospray ionisation mass spectrometry. | Woodcock, JC., et al. 2001. J Inorg Biochem. 84: 225-32. PMID: 11374585
- Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit. | Bonin, F., et al. 2004. J Biol Chem. 279: 52425-36. PMID: 15456758
- A new gliotoxin analogue from a marine-derived fungus Aspergillus fumigatus Fres. | Zhao, WY., et al. 2009. Nat Prod Res. 23: 203-7. PMID: 19235019
- Regulation of nonribosomal peptide synthesis: bis-thiomethylation attenuates gliotoxin biosynthesis in Aspergillus fumigatus. | Dolan, SK., et al. 2014. Chem Biol. 21: 999-1012. PMID: 25126990
- Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus. | Owens, RA., et al. 2015. Eukaryot Cell. 14: 941-57. PMID: 26150413
- Involvement of Sulfur in the Biosynthesis of Essential Metabolites in Pathogenic Fungi of Animals, Particularly Aspergillus spp.: Molecular and Therapeutic Implications. | Traynor, AM., et al. 2019. Front Microbiol. 10: 2859. PMID: 31921039
- The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB. | Pahl, HL., et al. 1996. J Exp Med. 183: 1829-40. PMID: 8666939
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bis(methylthio)gliotoxin (FR-49175), 1 mg | sc-201027 | 1 mg | $153.00 | |||
Bis(methylthio)gliotoxin (FR-49175), 2 mg | sc-201027A | 2 mg | $900.00 |