Biperiden (CAS 514-65-8)
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Biperiden is used in studies to investigate its anticholinergic properties, particularly focusing on its influence on the neurotransmitter acetylcholine in the central nervous system. By acting as an antagonist to muscarinic acetylcholine receptors, biperiden is useful for studying the modulation of neurotransmission and neural pathways associated with these receptors. Its mechanism involves competing with acetylcholine at its receptor sites, which allows exploration in the effects of reduced cholinergic activity on various physiological and neurological processes. Biperiden is utilized in models that aim to understand the dynamics of neurotransmitter systems, and its role is critical in advancing knowledge on how cholinergic disruptions can affect neurological function and behavior. Through these studies, biperiden helps in understanding the complex interactions within the central nervous system that could influence various biological and psychological states.
Biperiden (CAS 514-65-8) References
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- Effects of biperiden on sleep at baseline and after 72 h of REM sleep deprivation in the cat. | Salin-Pascual, RJ., et al. 1992. Psychopharmacology (Berl). 106: 540-2. PMID: 1579626
- Biperiden enhances L-DOPA methyl ester and dopamine D(l) receptor agonist SKF-82958 but antagonizes D(2)/D(3) receptor agonist rotigotine antihemiparkinsonian actions. | Domino, EF. and Ni, L. 2008. Eur J Pharmacol. 599: 81-5. PMID: 18851961
- Biperiden (an M1 antagonist) reduces memory consolidation of cocaine-conditioned place preference. | Zacarias, MS., et al. 2012. Neurosci Lett. 513: 129-31. PMID: 22336140
- Biperiden (M₁ antagonist) impairs the expression of cocaine conditioned place preference but potentiates the expression of cocaine-induced behavioral sensitization. | Ramos, AC., et al. 2012. Behav Brain Res. 231: 213-6. PMID: 22469627
- Transepithelial transport of biperiden hydrochloride in Caco-2 cell monolayers. | Abalos, IS., et al. 2012. Environ Toxicol Pharmacol. 34: 223-227. PMID: 22554863
- The antidepressant-like effects of biperiden may involve BDNF/TrkB signaling-mediated BICC1 expression in the hippocampus and prefrontal cortex of mice. | Zhou, D., et al. 2017. Pharmacol Biochem Behav. 157: 47-57. PMID: 28216067
- Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat. | Popelíková, A., et al. 2018. Psychopharmacology (Berl). 235: 2013-2025. PMID: 29680966
- Biperiden and mepazine effectively inhibit MALT1 activity and tumor growth in pancreatic cancer. | Konczalla, L., et al. 2020. Int J Cancer. 146: 1618-1630. PMID: 31291468
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- Effects of biperiden (cholinergic muscarinic m1/m4 receptor antagonist) on ethanol conditioned place preference in mice. | Palombo, P., et al. 2021. Neurosci Lett. 745: 135551. PMID: 33346074
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- A novel method for the therapeutic drug monitoring of biperiden in plasma by GC-MS using salt-assisted liquid-liquid microextraction. | Kul, A. and Sagirli, O. 2023. Clin Chim Acta. 543: 117322. PMID: 37001688
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Biperiden, 5 mg | sc-492228B | 5 mg | $72.00 | |||
Biperiden, 25 mg | sc-492228 | 25 mg | $166.00 | |||
Biperiden, 100 mg | sc-492228A | 100 mg | $520.00 |