Molecular structure of BIP-135, CAS Number: 941575-71-9
BIP-135 (CAS 941575-71-9)
Alternate Names:
3-(5-bromo-1-methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
Application:
BIP-135 is a GSK-3 inibitor with modest efficacy against PKC and PI3K
CAS Number:
941575-71-9
Molecular Weight:
421.24
Molecular Formula:
C21H13BrN2O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
BIP-135 is an inhibitor of glycogen synthase kinase-3 (GSK-3), and is found to be realatively selective for GSK-3β at 21 nM over GSK-3α with modest activity toward PKCβ (β1: 980 nM; β2: 219 nM), DYRK1B (590 nM), and PI3Kα (870 nM). BIP-135 was shown to have neuroprotective effects over cortical neuron model of oxidative stress. In a mouse model of spinal muscular atrophy, BIP-135 elevated SMN protein levels in vitro and extended median survival.
Inhibitor of:
Enzyme, GSK, PI 3-kinase, and YSK1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BIP-135, 5 mg | sc-364435 | 5 mg | $105.00 | |||
BIP-135, 25 mg | sc-364435A | 25 mg | $410.00 |