Molecular structure of Biotinyl Tyramide, CAS Number: 41994-02-9
Biotinyl Tyramide (CAS 41994-02-9)
Alternate Names:
[3aS-(3aα,4β,6aα)]-Hexahydro-N-[2-(4-hydroxyphenyl)ethyl]-2-oxo-, 1H-thieno[3,4-d]imidazole-5-pentanamide
CAS Number:
41994-02-9
Molecular Weight:
363.47
Molecular Formula:
C18H25N3O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Biotinyl tyramide is used in immunohistochemistry (IHC) and in situ hybridization (ISH) protocols. Tyramide Signal Amplification (TSA) is an immunohistochemistry technique designed to detect and quantify molecules such as proteins and nucleic acids. Biotinyl tyramide acts as an amplification reagent in these assays by catalyzing the deposition of a biotin polymer. Tyramide mimics tyrosine, forms a covalent bond with a tyrosine residues. This results in an increased signal intensity, allowing for enhanced detection and protein visualization. The biotinylated molecules can then be further detected using streptavidin-conjugated enzymes or fluorescent probes.
Biotinyl Tyramide (CAS 41994-02-9) References
- Localization of somatostatin receptors at the light and electron microscopial level by using antibodies raised against fusion proteins. | Helboe, L. and Møller, M. 2000. Prog Histochem Cytochem. 35: 3-64. PMID: 10904940
- A comparison of anti-biotin and biotinylated anti-avidin double-bridge and biotinylated tyramide immunohistochemical amplification. | Freedman, LJ. and Maddox, MT. 2001. J Neurosci Methods. 112: 43-9. PMID: 11640956
- Assessment of transcriptional gene activity in situ by application of HOPE-fixed, paraffin-embedded tissues. | Goldmann, T., et al. 2002. Pathol Res Pract. 198: 91-5. PMID: 11928870
- Advances in immunocytochemistry. | Van Noorden, S. 2002. Folia Histochem Cytobiol. 40: 121-4. PMID: 12056606
- Redefining the skin's pigmentary system with a novel tyrosinase assay. | Han, R., et al. 2002. Pigment Cell Res. 15: 290-7. PMID: 12100495
- Biotinyl-tyramide-based in situ hybridization signal patterns distinguish human papillomavirus type and grade of cervical intraepithelial neoplasia. | Evans, MF., et al. 2002. Mod Pathol. 15: 1339-47. PMID: 12481016
- Cytokine profile and supposed contribution to scarring in cicatricial pemphigoid. | Caproni, M., et al. 2003. J Oral Pathol Med. 32: 34-40. PMID: 12558956
- Ureaplasma in lung. 1. Localization by in situ hybridization in a mouse model. | Benstein, BD., et al. 2003. Exp Mol Pathol. 75: 165-70. PMID: 14516780
- In situ hybridization with novel biotinyl-tyramide: fundamental studies and its utility of the detection of human papilloma virus in tissue sections. | Hikino, T. 2007. Rinsho Byori. 55: 922-9. PMID: 18050669
- Quantification of α-tubulin isotypes by sandwich ELISA with signal amplification through biotinyl-tyramide or immuno-PCR. | Dráberová, E., et al. 2013. J Immunol Methods. 395: 63-70. PMID: 23851142
- Distribution of phosphorylated alpha-synuclein in non-diseased brain implicates olfactory bulb mitral cells in synucleinopathy pathogenesis. | Killinger, BA., et al. 2023. NPJ Parkinsons Dis. 9: 43. PMID: 36966145
- Biotinyl-tyramide: a novel approach for electron microscopic immunocytochemistry. | Mayer, G. and Bendayan, M. 1997. J Histochem Cytochem. 45: 1449-54. PMID: 9358846
- High sensitivity detection of HPV-16 in SiHa and CaSki cells utilizing FISH enhanced by TSA. | Adler, K., et al. 1997. Histochem Cell Biol. 108: 321-4. PMID: 9387924
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Biotinyl Tyramide, 100 mg | sc-503573 | 100 mg | $400.00 |