Molecular structure of Biotin-VAD-FMK, CAS Number: 1135688-15-1
Biotin-VAD-FMK (CAS 1135688-15-1)
See product citations (4)
Alternate Names:
Biotin-VAD-FMK also known as Biotin-Val-Ala-Asp(OMe)-Fluoromethyl ketone; pan-caspase inhibitor; Biotin-VAD(OMe)-FMK
Application:
Biotin-VAD-FMK is a cell permeable biotin-labeled caspase inhibitor used to identify active caspases in cell lysates
CAS Number:
1135688-15-1
Molecular Weight:
672.81
Molecular Formula:
C30H49FN6O8S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Biotin-VAD-FMK is a cell permeable biotin-labeled pan-caspase inhibitor used to identify active caspases in cell lysates. Biotin-VAD-FMK is an irreversible caspase inhibitor that covalently binds to the active cavity of a wide spectrum of active caspases. Affinity labeling of active caspases with biotin-VAD-fmk was carried out under conditions where more than 95% of caspase-3-like activity was inactivated in lysates from TNFα/ActD-treated cells. Biotin-VAD-FMK is an irreversible, pancaspase inhibitor. Inhibits TNFα-mediated apoptosis in vitro (IC50 = 0.7 μM).
Biotin-VAD-FMK (CAS 1135688-15-1) References
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- Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover. | Misaghi, S., et al. 2004. Chem Biol. 11: 1677-87. PMID: 15610852
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- Activation of gamma delta T cells by Borrelia burgdorferi is indirect via a TLR- and caspase-dependent pathway. | Collins, C., et al. 2008. J Immunol. 181: 2392-8. PMID: 18684928
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Inhibitor of:
Apoptosis, Caspase, and Chemical and Peptide Caspase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Biotin-VAD-FMK, 1 mg | sc-311290 | 1 mg | $398.00 | |||
Biotin-VAD-FMK, 5 mg | sc-311290A | 5 mg | $1938.00 |