Biotin - TAT (47 - 57)

Biotin-TAT (47-57) is a peptide compound composed of the vitamin biotin coupled to the trans-activator of transcription (TAT) peptide sequence spanning amino acids 47 to 57. This conjugate has gained considerable attention in scientific research due to its unique properties and diverse array of potential applications. The TAT peptide sequence, derived from the human immunodeficiency virus type 1 (HIV-1), is renowned for its ability to facilitate cellular uptake through receptor-independent mechanisms, primarily via direct translocation across cell membranes. By conjugating biotin to the TAT peptide, researchers have developed a versatile tool for cellular targeting and delivery of biotinylated molecules, such as proteins, nucleic acids, and nanoparticles. Biotin-TAT (47-57) has been widely utilized in various research fields, including molecular biology, drug delivery, and imaging studies. In research applications, this compound has been employed to enhance the intracellular delivery of biomolecules, enabling targeted delivery to specific cell types or tissues. Moreover, Biotin-TAT (47-57) has been explored for its potential in cell imaging studies, where it can be conjugated with fluorescent probes or imaging agents to visualize cellular processes or track molecular interactions in real-time. Overall, the conjugation of biotin to the TAT peptide sequence offers a powerful strategy for improving cellular delivery and targeting in research settings, enabling a wide range of applications across different scientific disciplines.