Molecular structure of Biotin Sulfone, CAS Number: 40720-05-6
Biotin Sulfone (CAS 40720-05-6)
Alternate Names:
(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic Acid 5,5-Dioxide
CAS Number:
40720-05-6
Molecular Weight:
276.31
Molecular Formula:
C10H16N2O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Biotin sulfone is initially discovered as a naturally occurring metabolite derived from biotin. Biotin, a growth factor found in trace amounts in all living cells, plays an essential role in various carboxylation reactions. Biotin sulfone acts as an inhibitor of biotin-dependent enzymes, including acetyl-CoA carboxylase, which is involved in fatty acid synthesis. Studies have shown the inhibitory effect of biotin sulfone on this enzyme. Moreover, biotin sulfone has shown interactions with other biotin-dependent enzymes like propionyl-CoA carboxylase and pyruvate carboxylase.
Biotin Sulfone (CAS 40720-05-6) References
- Advanced analysis of biotin metabolites in body fluids allows a more accurate measurement of biotin bioavailability and metabolism in humans. | Zempleni, J. and Mock, DM. 1999. J Nutr. 129: 494S-497S. PMID: 10064316
- [Effects of biotin sulfone on disposition toward experimental reflex epilepsy]. | PELLEGRINO, G. 1957. Boll Soc Ital Biol Sper. 33: 1191-2. PMID: 13510484
- A study of biotin sulfone inhibition of Lactobacillus arabinosus. | RAVEL, JM. and SHIVE, W. 1955. Arch Biochem Biophys. 54: 341-8. PMID: 14350781
- Isotope and affinity tags in photoreactive substance P analogues to identify the covalent linkage within the NK-1 receptor by MALDI-TOF analysis. | Sachon, E., et al. 2003. Anal Chem. 75: 6536-43. PMID: 14640725
- Antibiotin effect of homologs of biotin and biotin sulfone. | RUBIN, SH. and SCHEINER, J. 1949. Arch Biochem. 23: 400-10. PMID: 18141516
- Biotin sulfone as a new tool for synthetic oligosaccharide immobilization: application to multiple analysis profiling and surface plasmonic analysis of anti-Candida albicans antibody reactivity against alpha and beta (1-->2) oligomannosides. | Collot, M., et al. 2008. J Med Chem. 51: 6201-10. PMID: 18788729
- The differential effect of biotin sulfone and gamma-(3,4-ureylenecyclohexyl) butyric acid upon the microbiological activity of biotin and oxybiotin. | AXELROD, AE., et al. 1946. J Biol Chem. 163: 771. PMID: 20985652
- Biotin sulfone tagged oligomannosides as immunogens for eliciting antibodies against specific mannan epitopes. | Despras, G., et al. 2012. Bioorg Med Chem. 20: 1817-31. PMID: 22326546
- Biochemical characterization of dihydroorotase of Leishmania donovani: Understanding pyrimidine metabolism through its inhibition. | Tiwari, K., et al. 2016. Biochimie. 131: 45-53. PMID: 27650727
- Dissection of the anti-Candida albicans mannan immune response using synthetic oligomannosides reveals unique properties of β-1,2 mannotriose protective epitopes. | Sendid, B., et al. 2021. Sci Rep. 11: 10825. PMID: 34031516
- Rapid Synthesis of the epi-Biotin Sulfone via Tandem S,N-Carbonyl Migration/aza-Michael/Spirocyclization and Haller-Bauer Reaction. | Chavan, SP., et al. 2022. ACS Omega. 7: 17215-17222. PMID: 35647474
- Identification of biotin sulfone, bisnorbiotin methyl ketone, and tetranorbiotin-l-sulfoxide in human urine. | Zempleni, J., et al. 1997. Am J Clin Nutr. 65: 508-11. PMID: 9022537
- The pig is an appropriate model for human biotin catabolism as judged by the urinary metabolite profile of radioisotope-labeled biotin. | Mock, DM., et al. 1997. J Nutr. 127: 365-9. PMID: 9039841
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Biotin Sulfone, 500 mg | sc-503564 | 500 mg | $390.00 |